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Effects of Dietary Mulberry Leaf on Loperamide-Induced Constipation in Rats  

Lee, Jae-Joon (Department of Food and Nutrition, Chosun University)
Lee, Yu-Mi (Department of Food and Nutrition, Chosun University)
Jung, Seoung-Ki (Bioresource Inc.)
Kim, Keun-Young (Bioresource Inc.)
Lee, Myung-Yul (Department of Food and Nutrition, Chosun University)
Publication Information
Food Science and Preservation / v.15, no.2, 2008 , pp. 280-287 More about this Journal
Abstract
We investigated the effect of dietary mulberry leaf powder (MP) on loperamide-induced constipation in rats. Male Sprague-Dawley rats were given MP in their diets at a concentration of 0% 5% and 10% for 33 days. Rats were divided into 4 groups: normal diet group (NOR), normal diet and loperamide treated group (MPL0), 5% MP and loperamide treated group (MPL5), and 10% MP and loperamide treated group (MPL10). Constipation was induced by subcutaneous injection of loperamide (1.5 mg/kg body weight/day) for the final 5 days of the experiment Supplemental MP had no effect on the food efficiency ratio, but it reduced body weight gain and food intake in a concentration dependent manner. Administration of loperamide decreased food intake. MP had a concentration-dependent effect on decreasing total cholesterol, LDL-cholesterol, and triglycerides and on increasing HDL-cholesterol. Loperamide had no significant effect on serum lipid profiles. Loperamide decreased the number and wet weight of fecal pellets and fecal water content MP increased the number and wet weight of fecal pellets and fecal water content in a dose-dependent manner. In addition, MP increased gut transit time and transit speed, and the guts of mts treated with MP plus loperamide were longer than those of mts treated with loperamide alone. These results indicate that MP is an effective treatment for constipation.
Keywords
mulberry; constipation; loperamide; gastrointestinal function;
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