Browse > Article

Antioxidant, Anticancer Activities and Nitric Oxide Production of Euphoria longana Fermented with Lactic Acid Bacteria and Bacillus subtilis  

Shon, Mi-Yae (Dept. of Food and Nutrition, Gyeongsang National University)
Nam, Sang-Hae (Korea Fermented Food Research Institute)
Lee, Sang-Won (Korea Fermented Food Research Institute)
Publication Information
Food Science and Preservation / v.14, no.5, 2007 , pp. 531-537 More about this Journal
Abstract
Antioxidant anticancer activities and nitric oxide (NO) production of Vietnamese and Thai yonganyook (Euphoria longana) fermented with lactic acid bacteria and Bacillus subtilis were investigated. Total organic acid contents (TAC) of Thai raw yonganyook (473.49 mg/g, 89.2% of TAC) were higher 3.2 tims than those of Vietnamese raw yonganyook (148.48 mg/g, 86.8% of TAC) and major organic acids of two materials were formic acid and malic acid. Total free sugars contents of Vietnamese raw yonganyook (434.63 mg/g) were higher 1.2 times than those of Thai raw yonganyook (378.77 mg/g) and major free sugar of two materials welt sucrose, glucose and fructose. NO production of RAW264.7 cell treated with methanol extract of Vietnamese fermented yonganyook was shown to be a lower level than that of Thai fermented yonganyook. It's production by fermented yonganyook was strongly exhibited in low dose (0.2 mg/mL) than in high dose (1.0 mg/mL) as compared with raw yonganyook Electron-donating ability (EDA) of Vietnamese raw yonganyook ($41.72{\pm}3.59%$) at $600\;{\mu}g/assay$ was higher 1.4 times than that of Thai yonganyook ($30.20{\pm}4.8%$). EDA of Vietnamese yonganyook fermented with B. subtilis at $600\;{\mu}g/assay$ was $43.57{\pm}2.07%$ which was the highest level of all samples tested. Anticancer activity of raw yonganyook on human HeLa cell was similar to between Vietnamese and Thai yonganyook. In inhibitory effect of HepG2 cell growth, methanol extract of Thai yonganyook ($46.13{\pm}4.80%$) was higher than that of Vietnamese yonganyook ($33.07{\pm}0.92%$). Inhibitory activity of fermented yonganyook on HeLa and HepG2 cell growth were $39.21{\pm}1.46%$ and $48.07{\pm}1.63%$ when $200\;{\mu}g/assay$ of methanol extract of Vietnamese and Thai yonganyook fermented with B. subtilis were used, respectively.
Keywords
Euphoria longana; NO production; antioxidant; anticancer activity;
Citations & Related Records
Times Cited By KSCI : 14  (Citation Analysis)
연도 인용수 순위
1 Kim, D.H., Song, M.C., Choi, J.M., Kim, S.H., Kim, D.K., Chung, I.S., Park, M.H., Kwon, B.M. and Baek, N.I. (2004) Development of biologically active compounds from edible plant sources-VIII. Isolation of platelet aggregation inhibitory compounds from the arillus of Euphoria longana L. J. Korean Soc. Appl. Biol. Chem., 47, 130-134   과학기술학회마을
2 Juei, T.C., Ta, C.L. and Feng, L.H. (1995) Antihypertensive effect of corilagin in the rat. Can. J. Physiol. Pharmacol., 73, 1425-1429   DOI   ScienceOn
3 Okuyama, E., Ebihara, H., Takeuchi, H. and Yamazaki, M. (1999) Adenosine, the anxiolytic-like principle of the arillus of Euphoria longana. Planta Med., 65, 115-119   DOI   ScienceOn
4 Whang, S.M. (2002) Effects of the Euphoria longana L. and Hoelen cum Pini Radix on the serotonin contents of immobilzation stressed mice brain. MS thesis, Daegu Haany Univ., Daegu, Korea
5 Kim, N.J. and Hong, N.D. (1996) Studies on the processing of crude drugs on the constituents and biological activities of Glycyrrhizae radix by processing. Kor. J. Pharmacogn., 27, 196-206   과학기술학회마을
6 Kim, D.H., Han, S.B., Park, J.S. and Han, M.J. (1994) Fermentation of antler and its biological activity. Kor. J. Pharmacogn., 25, 233-237   과학기술학회마을
7 Han, J.Y., Goo, D.H., Han, M.S. and Ryu, G.H. (2007) Comparison of fermentability and characteristics of fermented broth for white ginseng, red ginseng and extruded white ginseng. Food Eng. Progress, 11, 119-126
8 Chu, Y.H., Chan, C.L. and Hsu, H.F. (2000) Flavonoid content of several vegetables and their antioxidant mushrooms(Agaricus bisporus). J. Sci. Food Agric., 80, 561-566   DOI   ScienceOn
9 Jang, H.D., Kim, H.J., Min, B.J., Cho, J.H., Chen, Y.G., Yoo, J.S., Lee, J.J., Han, M.H. and Kim, I.H. (2007) Effects of fermented wild-ginseng culture by-products on growth performance, blood characteristics, meat quality and ginsenoside concentration of meat in finishing pigs. J. Anim. Sci. Technol., 49, 329-340   DOI
10 Ryu, K.Y., Seo, H.Y., Han, K.J., Jeong, Y.M., Kim, K.S., Hong, K.J. and You, S.H. (2007) Changes of volatile organic compounds of Rhus verniciflua S. Bark by fermentation. Korean J. Food Preserv., 14, 308-314   과학기술학회마을
11 Kim, E.Y., Baik, I.H., Kim, J.H., Kim, S.R. and Rhyu, M.R. (2004) Screening of the antioxidant activity of some medicinal plants. Korean J. Food Sci. Technol., 36, 333-338   과학기술학회마을
12 Feng, L.H., Feng, H.L. and Juei, T.C. (1994) Influence of acetonylgeraniin, a hydrolyzable tannin from Euphoria longana, on orthostatic hypertension in a rat model. Planta Med., 60, 297-300   DOI   ScienceOn
13 Kim, S.D., Ku, Y.S., Lee, I.Z., Kim, M.K. and Park, I.K. (2000) Major chemical components in fermented beverages of Liriopis tuber. J. East Asian Dietary Life, 10, 281-287
14 Kim, C.H., Kwon, M.C., Kim, H.S., Bae, G.J., Ahn, J.H., Chio, G.P., Choi, Y.B., Ko, J.R. and Lee, H.Y. (2007) Enhancement of immune activities of Kadsura japonica Dunal through conventional fermentation process. Korean J. Med. Crop Sci., 15, 162-169   과학기술학회마을
15 Kim, S.H., Kang, M.Y. and Nam, S.H. (2005) Modulatory effects of 21 kinds of medicinal herbs including herba Pogostemi(Agastache rugosa) on nitric oxide production in macrophage cell line RAW264.7 cells. J. Korean Soc. Appl. Biol. Chem., 48, 411-417
16 Kang, S.Y., Han, J.H. and Cho, N.G. (1997) Effect of several herb drugs Hep G2 cells and mouse peritoneal macrophage. J. Herbology, 12, 95-111
17 Park, S.J., Kim, D.H., Paek, N.S. and Kim, S.S. (2006) Preparation and quality characteristics of the fermentation product of ginseng by lactic acid bacteria(FGL). J. Ginseng Res., 30, 88-94   과학기술학회마을   DOI
18 Ryu, J.Y., Kim, J.S. and Kang, S.S. (2002) Quality evaluation and components of Euphoria longana. Kor. J. Pharmacogn., 33, 191-193   과학기술학회마을
19 Jwa, C.S., Yang, Y.T. and Kok, J.S. (2000) Changes in free sugars, organic acid, free amino acids and minerals by harvest time and parts of Acanthopanax koreanum. J. Korean Soc. Agric. Chem. Biotechnol., 43, 106-109
20 Jung, S.J., Lee, J.H., Seong, N.S., Lee, S.E. and Baek, N.I. (2004) Screening for antioxidant activity of plant medicinal extracts. J. Korean Soc. Appl. Biol. Chem., 47, 135-140   과학기술학회마을
21 Yee, S.T., Jeong, Y.R., Ha, M.H., Kim, S.H., Byun, M.W. and Jo, S.K. (2000) Induction of nitric oxide and $TNF-{\alpha}$ by herbal plant extracts in mouse macrophages. J. Korean Soc. Food Sci. Nutr., 29, 342-348   과학기술학회마을
22 Kleiman, R., Earle, F.R. and Wolff, I.A. (1968) Dihydrosterculic acid, a major fatty acid component of Euphoria longan seed oil. Lipids, 4, 317-320
23 Kim, K.A., Nam, H.Y., Moon, J.H., Jeong, J.S., Lim, Y. and Kai, H. (2002) Role of NO in activation of $NF_{\kappa}B$ by PM2.5 in lung epithelial cells. Tuberculosis  Respiratory Dis., 52, 616-626   DOI
24 한대석. (1988) 생약학. 동명사, 서울. p.291
25 Ackman, R.G. and Hooper, S.N. (1970) Hydrolysis products of the major fatty acids from Euphoria longana seed oil. J. Am. Oil Chem. Soc., 47, 525-529   DOI
26 Hansen, M.B., Neilsen, S.E. and Berg, K. (1989) Reexamination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119, 203-210   DOI   ScienceOn
27 Mahato, S.B., Sahu, N.P. and Chakravarti N. (1971) Chemical investigation on the leaves of Euphoria longana. Phytochemistry, 10, 2847-2848   DOI   ScienceOn
28 Ha, Y.K. (2002) Effects of the Longanae Arillus on the norepinephrine contents of immobilzation stressed mice brain. MS thesis, Kyungwon Univ., Seongnam, Korea
29 Kim, D.H., Kim, D.W., Choi, S.Y. and Park, C.H. (2005) 5-hydroxymethyl- 2-furfuraldehyde, anticonvulsant furan from the arillus of Euphoria longana L. Agric. Chem. Biotechnol., 48, 32-34
30 Jae, J.H. (2007) Antidiabetic and oxidative stress relieving effects of fermented red ginseng. MS thesis, Busan National Univ., Busan, Korea
31 Lee, S.E., Seong, N.S., Park, C.G. and Seong, J.S. (2002) Screening for antioxidative activity of oriental medicinal plant materials. Korean J. Med. Crop Sci., 10, 171-176
32 Chi, Y.S., Cheon, B.S. and Kim, H.P. (2001) Effect of wogonin, a plant flavone from Scutellafia radix, on the suppression of cyclooxygenase-2 and the induction of inducile nitric oxide synthase in lipopolysaccharide- treated RAW264.7 cell. Biochem. Pharmacol., 61, 1195-1203   DOI   ScienceOn
33 Choi, U., Shin, D.H., Chang, Y.S. and Shin, J.I. (1992) Screening of natural antioxidant from plant and their antioxidative effect. Korean J. Food Sci. Technol., 24, 142-148