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Water-extract of Helianthus annuus Seed Exhibits Potent Anti-asthma Activity In Vitro and In Vivo  

Heo Jin-Chul (Departments of Food Science & Technology, Kyungpook National University)
Park Ja-Young (Departments of Food Science & Technology, Kyungpook National University)
Woo Sang-Uk (Departments of Food Science & Technology, Kyungpook National University)
Chung Shin-Kyo (Departments of Food Science & Technology, Kyungpook National University)
Jeong Kyu-Shick (Departments of Veterinary Medicine, Kyungpook National University)
Lee Jin-Man (Department of Herbal BioFood Science, Kyongbuk College of Science)
Ma Jin-Yeol (Korea Institute of Oriental Medicine)
Lee Sang-Han (Departments of Food Science & Technology, Kyungpook National University)
Publication Information
Food Science and Preservation / v.13, no.4, 2006 , pp. 495-500 More about this Journal
Abstract
In order to investigate whether antioxidant biomaterials inhibits IL-4 and/or IL-13 expression in vitro and in vivo, we carried out antioxidant assays by enzyme or cell-based assays with Helianthus annuus extract. Antioxidant assays include DPPH, FRAP, hydroxyl radical assays. Helianthus annuus extract exhibited SOD scavenging activity, and had different patterns by each solvent extracted reaction. DW extract inhibited oxidative stress by $H_2O_2$ that induced apoptosis. We measured $CD4^+$ cell and IL-/13 cytokine expression in a classical mouse animal model. The result show that Helianthus annuus extract showed strung inhibition of immune response in the lung. These result suggest that Helianthus annuus extract can reduce inflammation induced by n mouse asthma model.
Keywords
Helianthus annuus; Asthma animal models; IL-4; IL-13; $CD4^+$ cells;
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