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Anticancer and Immuno-activity of Methanol Extract from Onion Kochujang  

Kim Jae-Yong (Research Institute of Basic Sciences, Sunchon National University)
Park Kyung-Wook (Department of Food Science and Nutrition, Sunchon National University)
Yang Hyun-Sook (Department of Food Science and Nutrition, Sunchon National University)
Cho Young-Sook (Department of Food Science and Nutrition, Sunchon National University)
Jeong Chang-Ho (Division of Applied Life Sciences, Graduate School, Gyeongsang National University)
Shim Ki-Hwan (Division of Applied Life Sciences, Graduate School, Gyeongsang National University)
Yee Sung-Tae (Department of Biology, Sunchon National University)
Seo Kwon-Il (Department of Food Science and Nutrition, Sunchon National University)
Publication Information
Food Science and Preservation / v.12, no.2, 2005 , pp. 173-178 More about this Journal
Abstract
Antitumor activities of methanol extract from onion Kochujang (MEOK) were investigated by using aflatoxin $B_{1}-mediated$ Salmonella typhimurium mutagenicity and the model of cytotoxicity on the cancer cell lines. Their immune activities were also investigated using mouse spleen cells and macrophage cell lines, respectively. MEOK showed the enhanced antimutagenicity in a dose-dependent manner. relative to the control group. MEOK decreased over $20\%$ of the proliferation of the A549(lung cancer cell) and MCF(breast cancer cell) cell lines at $1,000\;{\mu}g/mL$ concentration compared with the control cells. The proliferation of mouse spleen cells and the NO production in marcrophage cell lines treated MEOK were increased in a dose-dependent manner, respectively. The activities were higher than that of the control(no added onion) Kochujang.
Keywords
onion; Kochujang; anticancer activity; immuno-activity;
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