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http://dx.doi.org/10.3746/jkfn.2016.45.10.1508

Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats  

You, Yanghee (College of Human Ecology, Chonnam National University)
Lee, Hyunmi (Division of Food and Nutrition, Chonnam National University)
Chung, Changsik (NutriPlan Co., Ltd.)
Lee, Min-Jae (NutriPlan Co., Ltd.)
Jun, Woojin (Division of Food and Nutrition, Chonnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.10, 2016 , pp. 1508-1512 More about this Journal
Abstract
This study was performed to investigate the ameliorating effect of a mixture of extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. (leaf), and Camellia sinensis (seed) (MIX) on acute ethanol-induced hangover in Sprague-Dawley rats. Plasma ethanol and acetaldehyde levels in MIX-treated rats significantly decreased at 3 h and 5 h after acute ethanol administration (25%, 3 g/kg body weight/d) as compared to ethanol-treated rats. Hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly higher in MIX-treated rats than in ethanol-treated rats. MIX exhibited high ADH and ALDH activities on direct assays using S9 rat liver fraction for ethanol metabolic enzymes clearance action. These results suggest that MIX could alleviate ethanol-induced hangover symptoms by elevating activities related to hepatic ethanol-metabolizing enzymes against ethanol induced metabolites, and MIX should be further developed to be a new anti-hangover material.
Keywords
alcohol; acetaldehyde; alcohol dehydrogenase; acetaldehyde dehydrogenase; hangover;
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Times Cited By KSCI : 11  (Citation Analysis)
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