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http://dx.doi.org/10.3746/jkfn.2015.44.12.1785

Anti-Diabetic, Alcohol Metabolizing Enzyme, and Hepatoprotective Activity of Acer tegmentosum Maxim. Stem Extracts  

Cho, Eun Kyung (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Jung, Kyung Im (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Choi, Young Ju (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.12, 2015 , pp. 1785-1792 More about this Journal
Abstract
This study was carried out to investigate the antidiabetic, alcohol metabolism, anti-inflammatory, and hepatoprotective effects of Acer tegmentosum extracts (ATE). A. tegmentosum has been traditionally used as a folk medicine to treat hepatic disorders. The antioxidative activities of ATE were measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and superoxide (SOD) assay. DPPH radical scavenging and SOD activities of ATE were about 89% and 82.9% at $0.5{\mu}g/mL$, respectively. Alcohol dehydrogenase and acetaldehyde dehydrogenase activities were 118.0% and 177% at 2 mg/mL, respectively. ${\alpha}-Glucosidase$ inhibitory activity of ATE was 75% higher at $50{\mu}g/mL$ and remarkably increased in a dose-dependent manner. Nitric oxide productions in macrophage RAW 264.7 cells stimulated by lipopolysaccharide was reduced to 16.7% by addition of ATE at 1 mg/mL. ATE showed significant protective effects against tacrine-induced cytotoxicity in Hep G2 cells at $100{\mu}g/mL$. Based on our results, we conclude that ATE may be used as a major pharmacological agent and anti-diabetic, anti-hepatitis, and anti-inflammatory remedy.
Keywords
Acer tegmentosum; anti-inflammatory; ${\alpha}-glucosidase$; alcohol dehydrogenase; hepatoprotective;
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