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http://dx.doi.org/10.3746/jkfn.2014.43.12.1808

Comparison of Effect of Water and Ethanolic Extract from Roots and Leaves of Allium hookeri  

Lee, Kwan-Wook (Department of Food Science and Technology, Korea National University of Transportation)
Kim, Yon-Suk (Department of Biotechnology, Konkuk University)
Park, Pyo-Jam (Department of Biotechnology, Konkuk University)
Jeong, Jae-Hyun (Department of Food Science and Technology, Korea National University of Transportation)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.12, 2014 , pp. 1808-1816 More about this Journal
Abstract
The aim of this study was to evaluate the antioxidant activities and anti-inflammatory effects of water and ethanolic extracts from Allium hookeri roots and leaves. Antioxidant activities of Allium hookeri extracts were determined based on various radical scavenging activities using an ESR spectrophotometer, ferric reducing antioxidant power, 2,2'-azinobis-(3-ethybenzothiazoline-6-sulfonic acid) radical scavenging activity, and oxygen radical absorbance capacity assays. In addition, we investigated anti-inflammatory effects of Allium hookeri extract on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. We also explored the effects of extract from Allium hookeri root on suppression of pro-inflammatory mediators such as nitric oxide (NO) and pro-inflammatory cytokines such as IL-6 and TNF-${\alpha}$ against LPS-induced activation of RAW264.7 cells. Our results demonstrated superior antioxidant activity for leaf extract of Allium hookeri compared to extract from root of Allium hookeri. On the other hand, root extract of Allium hookeri showed better anti-inflammatory activity compared to leaf extract. Our study suggests that Allium hookeri extract exhibits strong antioxidant activity and anti-inflammatory effects and can be developed as a potential therapeutic candidate for diseases involving oxidative stress and inflammation.
Keywords
antioxidant activity; anti-inflammatory effect; Allium hookeri; reactive oxygen species;
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