Inhibitory Effects of Chios Mastic Gum on Gastric Acid Secretion by Histamine-Related Pathway in a Rat Model and Primary Parietal Cells
![]() |
Nam, Da-Eun
(Department of Medical Nutrition, Kyung Hee University)
Kim, Ok Kyung (Department of Medical Nutrition, Kyung Hee University) Shim, Tae Jin (Jinyong Co. Ltd.) Lee, Jum Kyun (Health Balance Co. Ltd.) Hwang, Kwon-Tack (Department of Food and Nutrition, Nambu University) |
1 | Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. 1999. Helicobacter pylori virulence and genetic geography. Science 284: 1328-1333. DOI |
2 | Kay HH, Grindle KM, Magness RR. 2000. Ethanol exposure induces oxidative stress and impairs nitric oxide availability in the human placental villi: a possible mechanism of toxicity. Am J Obstet Gynecol 182: 682-688. DOI |
3 | Bilici D, Suleyman H, Banoglu ZN, Kiziltunc A, Avci B, Ciftcioglu A, Bilici S. 2002. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig Dis Sci 47: 856-861. DOI |
4 | Kim JH, Kim HY, Kim NY, Kim SW, Kim JG, Kim JJ, Roe IH, Seo JK, Sim JG, Ahn H, Yoon BC, Lee SW, Lee YC, Chung IS, Jung HY, Hong WS, Choi KW. 2001. Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea. J Gastroenterol Hepatol 16: 969-975. DOI ScienceOn |
5 | Bujanda L. 2000. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 95: 3374-3382. DOI ScienceOn |
6 | Szabo S, Trier JS, Brown A, Schnoor J. 1985. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88: 228-236. DOI ScienceOn |
7 | Liu ES, Cho CH. 2000. Relationship between ethanol-induced gastritis and gastric ulcer formation in rats. Digestion 62: 232-239. DOI ScienceOn |
8 | Helander HF, Keeling DJ. 1993. Cell biology of gastric acid secretion. Baillieres Clin Gastroenterol 7: 1-21. DOI |
9 | Chew CS. 1991. Intracellular mechanisms in control of acid secretion. Curr Opin Gastroenterol 7: 856-862. DOI |
10 | Mardh S, Song YH, Carlsson C, Bjorkman T. 1987. Mechanisms of stimulation of acid production in parietal cells isolated from the pig gastric mucosa. Acta Physiol Scand 131: 589-598. DOI ScienceOn |
11 | Chew C. 1993. Peptidergic regulation of gastric acid secretion. In Gastrointestinal Regulatory Peptides. Springer, Berlin, Heidelberg, Germany. p 199-252. |
12 | Uedo N, Takeuchi Y, Yamada T, Ishihara R, Ogiyama H, Yamamoto S, Kato M, Tatsumi K, Masuda E, Tamai C, Yamamoto S, Higashino K, Iishi H, Tatsuta M. 2007. Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. Am J Gastroenterol 102: 1610-1616. DOI ScienceOn |
13 | Benhammou N, Bekkara FA, Panovska TK. 2008. Antioxidant and antimicrobial activities of the Pistacia lentiscus and Pistacia atlantica extracts. Afr J Pharm Pharmacol 2: 22-28. |
14 | Giaginis C, Theocharis S. 2011. Current evidence on the anticancer potential of chios mastic gum. Nutr Cancer 63: 1174-1184. DOI |
15 | Kaliora AC, Stathopoulou MG, Triantafillidis JK, Dedoussis GV, Andrikopoulos NK. 2007. Alterations in the function of circulating mononuclear cells derived from patients with Crohn's disease treated with mastic. World J Gastroenterol 13: 6031-6036. DOI ScienceOn |
16 | Al-Said MS, Ageel AM, Parmar NS, Tariq M. 1986. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol 15: 271-278. DOI ScienceOn |
17 | Kottakis F, Kouzi-Koliakou K, Pendas S, Kountouras J, Choli-Papadopoulou T. 2009. Effects of mastic gum Pistacia lentiscus var. Chia on innate cellular immune effectors. Eur J Gastroenterol Hepatol 21: 143-149. DOI |
18 | Takahashi K, Fukazawa M, Motohira H, Ochiai K, Nishikawa H, Miyata T. 2003. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J Periodontol 74: 501-505. DOI |
19 | Triantafyllou A, Chaviaras N, Sergentanis TN, Protopapa E, Tsaknis J. 2007. Chios mastic gum modulates serum biochemical parameters in a human population. J Ethnopharmacol 111: 43-49. DOI ScienceOn |
20 | Al-Habbal MJ, Al-Habbal Z, Huwez FU. 1984. A doubleblind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin Exp Pharmacol Physiol 11: 541-544. DOI |
21 |
Nakada SL, Crothers JM Jr, Machen TE, Forte JG. 2012. Apical vacuole formation by gastric parietal cells in primary culture: effect of low extracellular |
22 | Gioxari A, Kaliora AC, Papalois A, Agrogiannis G, Triantafillidis JK, Andrikopoulos NK. 2011. Pistacia lentiscus resin regulates intestinal damage and inflammation in trinitrobenzene sulfonic acid-induced colitis. J Med Food 14: 1403-1411. DOI ScienceOn |
23 |
Osawa H, Kita H, Ohnishi H, Hoshino H, Mutoh H, Ishino Y, Watanabe E, Satoh K, Sugano K. 2006. Helicobacter pylori eradication induces marked increase in |
24 | Chadzopulu A, Koukouliata A, Theodosopoulou E, Adraniotis J. 2011. Unique mastic resin from chios. Prog Health Sci 1: 131-136. |
25 |
Papalois A, Gioxari A, Kaliora AC, Lymperopoulou A, Agrogiannis G, Papada E, Andrikopoulos NK. 2012. Chios mastic fractions in experimental colitis: implication of the nuclear factor |
26 | Chen D, Zhao CM. 2010. Complexity of gastric acid secretion revealed by targeted gene disruption in mice. Curr Pharm Des 16: 1235-1240. DOI |
27 | Schubert ML. 2007. Gastric secretion. Curr Opin Gastroenterol 23: 595-601. DOI ScienceOn |
28 | Zhou L, Satoh K, Takahashi K, Watanabe S, Nakamura W, Maki J, Hatano H, Takekawa F, Shimada C, Sakagami H. 2009. Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In Vivo 23: 583-589. |
29 | Mahmoudi M, Ebrahimzadeh MA, Nabavi SF, Hafezi S, Nabavi SM, Eslami SH. 2010. Antiinflammatory and antioxidant activities of gum mastic. Eur Rev Med Pharmacol Sci 14: 765-769. |
30 | Kim MS, Kim N, Kim SE, Jo HJ, Shin CM, Lee SH, Park YS, Hwang JH, Kim JW, Jeong SH, Lee DH, Kim JM, Jung HC. 2013. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. Helicobacter 18: 135-142. DOI ScienceOn |
31 | Triantafyllou A, Bikineyeva A, Dikalova A, Nazarewicz R, Lerakis S, Dikalov S. 2011. Anti-inflammatory activity of chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Nutr J 10: 64. DOI |
![]() |