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http://dx.doi.org/10.3746/jkfn.2013.42.11.1744

Protective Effect of Mulberry and Lithospermum erythrorhizon Extracts on Anti-aging against Photodamage  

Jeong, Yoo Seok (Biohealth Convergence Center, Daegu Technopark)
Jung, Hee Kyoung (Biohealth Convergence Center, Daegu Technopark)
Hong, Joo-Heon (Dept. of Food Science and Technology, Catholic University of Daegu)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.11, 2013 , pp. 1744-1752 More about this Journal
Abstract
We investigated the protective effect of UVB inducing photodamage from mulberry extract (ME) and Lithospermum erythrorhizon extract (LE). The contents of total anthocyanin and shikonin as a color compound of ME and LE were 4.92 mg/g and 9.58 mg/g, respectively. The electron donating ability and superoxide radical scavenging activity of ME were 84.32% and 76.34%, respectively. The oxygen radical absorbance capacity of the ME ($545.37{\mu}moles$ TE/g) was higher than LE ($427.18{\mu}moles$ TE/g). MMP-1 production in the HS68 cells were exposed to UVB suppressed by treatment with $200{\mu}g/mL$ of ME (68.6%) and LE (32.7%). ME and LE were applied to a skin aging mouse model, which was induced by the irradiation of UVB to the backs of hairless mice. The value of skin erythema index, wrinkle depth and thickness, epidermis thickness, and collagenous fiber damage in the experiment groups (MEL: ME 3%, MEM: ME 5%, MEH: ME 7%, LEL: LE 3%, LEM: LE 5%, LEH: LE 7%) were remarkably reduced than in the control group (only UVB exposure group), while water capacity increased. The level of total wrinkles depth in the skin was decreased to be 30% of the control group by MEH and LEM. These results suggest that ME and LE are useful cosmetic materials for skin protection against UVB-inducing.
Keywords
mulberry; Lithospermum erythrorhizon; UVB; anti-aging; protective effect;
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Times Cited By KSCI : 13  (Citation Analysis)
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