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http://dx.doi.org/10.3746/jkfn.2013.42.11.1736

Effects of Antioxidant and Blood Flow Improvement of Grape Leaf Extract and Resveratrol from Vitis romaneti  

Kang, Hyun Ju (Dept. of Healthcare & Science, Jeonju University)
Kim, Hyeon Soo (Dept. of Healthcare & Science, Jeonju University)
Jeon, In Hwa (Dept. of Healthcare & Science, Jeonju University)
Mok, Ji Ye (Dept. of Healthcare & Science, Jeonju University)
Han, Kyeong Soo (Hansorganic)
Jang, Seon Il (Dept. of Healthcare & Science, Jeonju University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.11, 2013 , pp. 1736-1743 More about this Journal
Abstract
The purpose of this study is to investigate the effects of 80% ethanol grape leaf extract (VGLE) and resveratrol (VGLR) from Vitis romaneti on antioxidant of red blood cells (RBC) of rat and efficacy of blood flow improvement in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. RBC oxidative hemolysis and plasma lipid peroxidation induced by the aqueous peroxyl radical generator 2,2'-azobis(2-amidinopropane) dihydrochloride were significantly suppressed by VGLE or VGLR in a dose-dependent manner. The $FeCl_3$ treatment seriously damaged the carotid artery: the walls of the artery and blood flow. However, VGLE or VGLR administration has ameliorated the blood flow and suppressed thrombus in blood vessels. These results suggest that VGLE or VGLR ameliorates the oxidative stress of RBC and thrombosis against blood vessel damage.
Keywords
Vitis romaneti; grape leaf extract; resveratrol; antioxidant; blood flow improvement;
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1 Sadrzadeh SM, Graf E, Panter SS, Hallaway PE, Eaton JW. 1984. Hemoglobin. A biologic fenton reagent. J Biol Chem 259: 14354-14356.
2 Clemens MR, Ruess M, Bursa Z, Waller HD. 1987. The relationship between lipid composition of red blood cells and their susceptibility to lipid peroxidation. Free Radic Res Commun 3: 265-271.   DOI
3 Kang HJ, Mok JY, Cho JK, Jeon IH, Kim HS, Park JM, Jeong SI, Shim JS, Jang SI. 2012. Protective effects of leaf and flower extracts from Cirsium japonicum var. ussuriense on oxidative damage in normal human erythrocytes and plasma. Kor J Pharmacogn 43: 66-71.   과학기술학회마을
4 Xiromeritis K, Dalainas I, Stamatakos M, Katsikas V, Martinakis V, Stamatelopoulos K, Psarros V. 2012. Acute carotid stent thrombosis after carotid artery stenting. Eur Rev Med Pharmacol Sci 16: 355-362.
5 Marques MA, Murad FF, Ristow AV, Silveira PR, Pinto JE, Gress MH, Massiere B, Cury JM, Vescovi A. 2010. Acute carotid occlusion and stroke due to antiphospholipid antibody syndrome: case report and literature review. Int Angiol 29: 380-384.
6 Xu W, Wang TY, Becker RC. 2011. Hematologic diseases: from within the heart. Rev Esp Cardiol 64: 606-613.   DOI
7 Warner TD, Nylander S, Whatling C. 2011. Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Br J Clin Pharmacol 72: 619-633.   DOI   ScienceOn
8 Williams MJ, Sutherland WH, McCormick MP, Yeoman DJ, de Jong SA. 2005. Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res 19: 314-319.   DOI   ScienceOn
9 Lee JJ, Yang H, Yoo YM, Hong SS, Lee D, Lee HJ, Lee HJ, Myung CS, Choi KC, Jeung EB. 2012. Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease. J Atheroscler Thromb 19: 516-522.   DOI   ScienceOn
10 Li CL, Cao YL, He YH, Gu J, Zhang Z, Zhou MD. 1996. Collecting wild Vitis in China. Plant Genetic Resources Newsletter 106: 41-42.
11 God JM, Tate P, Larcom LL. 2007. Anticancer effects of four varieties of muscadine grape. J Med Food 10: 54-59.   DOI   ScienceOn
12 Renaud S, de Lorgeril M. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523-1526.   DOI   ScienceOn
13 Formica JV, Regelson W. 1995. Review of biology of quercetin and related bioflavonoids. Food Chem Toxicol 33: 1061-1080.   DOI   ScienceOn
14 Hseu YC, Chang WC, Hseu YT, Lee CY, Yech YJ, Chen PC, Chen JY, Yang HL. 2002. Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life Sci 71: 469-482.   DOI   ScienceOn
15 Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
16 Lockyer S, Kambayashi J. 1999. Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis. J Cardiovasc Pharmacol 33: 718-725.   DOI   ScienceOn
17 Mancini M, Rubba P. 2000. Ischemic cardiopathy: risk factors and their biological role. Ital Heart J 2: 17-22.
18 Wang X, Cheng Q, Xu L, Feuerstein GZ, Hsu MY, Smith PL, Seiffert DA, Schumacher WA, Ogletree ML, Gailani D. 2005. Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice. J Thromb Haemost 3: 695-702.   DOI   ScienceOn
19 Chu LM, Robich MP, Lassaletta AD, Feng J, Laham RJ, Burgess T, Clements RT, Sellke FW. 2011. Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia. Surgery 150: 390-399.   DOI   ScienceOn
20 Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CF. 2010. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 91: 1590-1597.   DOI   ScienceOn
21 Kawashima S. 1969. The possible role of lipoperoxide in aging. Nagoya J Med Sci 32: 303-326.
22 Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. 2000. Aging, habitual exercise, and dynamic arterial compliance. Circulation 102: 1270-1275.   DOI   ScienceOn
23 Wiseman H. 1996. Dietary influences on membrane function: Impotent in protection against oxidative damage and disease. Nutr Biochem 7: 2-6.   DOI   ScienceOn
24 Bouayed J, Bohn T. 2010. Exogenous antioxidants - Doubleedged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev 3: 228-237.   DOI
25 Decker EA, Crum AD, Calvert JT. 1992. Differences in the antioxidant mechanism of carnosine in the presence of copper and iron. J Agric Food Chem 40: 756-759.   DOI
26 Halliwell B, Gutteridge JM. 1990. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186: 1-85.   DOI