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http://dx.doi.org/10.3746/jkfn.2013.42.10.1585

Effects of Exercise Training on the Relationship with Brain-derived Neurotrophic Factor Expression and Leptin mRNA Expression in Hypothalamus, Serum Leptin, and Anti-obesity in High-fat Diet-induced Obese Rats  

Woo, Sang Heon (Laboratory of Exercise Biochemistry and Physiology, Dept. of Physical Education, Dong-A University)
Kang, Sunghwun (Laboratory of Exercise Biochemistry and Physiology, Dept. of Physical Education, Dong-A University)
Woo, Jinhee (Laboratory of Exercise Biochemistry and Physiology, Dept. of Physical Education, Dong-A University)
Shin, Ki Ok (Laboratory of Exercise Biochemistry and Physiology, Dept. of Physical Education, Dong-A University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.10, 2013 , pp. 1585-1591 More about this Journal
Abstract
The purpose of this study is to examine how to relate with hypothalamus protein BDNF and mRNA leptin expression, and test the effect of exercise training upon anti-obesity in high-fat induced obese rats. Weight and plasma TC of the high-fat diet group (HF) significantly reduced in comparison to those in the high-fat diet and training group (HF-T), high-fat diet and normal diet group (HF-ND), and high-fat diet, training, and normal diet group (HF-ND+T) (P<0.05). Plasm TG of the HF group significantly decreased in comparison to the HF-ND+T group (P< 0.05). The plasma leptin level significantly reduced in the HF-T group in comparison to the HF group, in the HF-ND group compared to the HF-T group, and the HF-ND+T group in comparison to the HF-ND group (P<0.05, respectively). All groups were significantly increased in hypothalamus BDNF protein expression in comparison to the HF group. In hypothalamus leptin mRNA expression, the HF-T and HF-ND groups reduced, but the HF-NF+T group increased in comparison to the HF group. This result suggests that it shows the effect of exercise training upon anti-obesity in high-fat diet induced obese rats and the combined exercise and/or normal diet may affect the optimal obesity improvement and prevention in appetite and weight control.
Keywords
exercise; high-fat diet; BDNF; leptin; obesity;
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