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http://dx.doi.org/10.3746/jkfn.2011.40.2.321

Antihyperglycemic of Gleditschiae Spina Extracts in Streptozotocin-Nicotinamide Induced Type 2 Diabetic Rats  

Park, Jae-Hee (Dept. of Food and Nutrition, Kyungnam University)
Chu, Won-Mi (Dept. of Food and Nutrition, Kyungnam University)
Lee, Jeung-Min (Dept. of Food Science and Biotechnology, Kyungnam University)
Park, Hae-Ryong (Dept. of Food Science and Biotechnology, Kyungnam University)
Park, Eun-Ju (Dept. of Food and Nutrition, Kyungnam University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.40, no.2, 2011 , pp. 321-326 More about this Journal
Abstract
The aim of the present study was to investigate antihyperglycemic effect of Gleditschiae Spina (GS) in streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic rats. The rats were divided into four groups: normal control (NC), diabetic control (DC), diabetic rats supplemented with acarbose (AC, 4 mg/kg), and with GS ethanol extracts (GSE, 50 mg/kg). Weekly fasting blood glucose (FBG) for 10 weeks and oral glucose tolerance test (OGTT) at 10th week were monitored using glucose oxidase-peroxidase reactive strips. The FBG level was significantly reduced in AC group after 8 weeks and in GSE group at the end of period. The AUCs for the glucose response from OGTT and blood glucose level after sacrifice were significantly lower in the AC and GSE groups than the DC group. GSE supplementation significantly increased plasma total radical-trapping antioxidant potential (TRAP) in STZ-NA-induced diabetic rats, compared with DC group. The present study indicates that GSE could ameliorate type 2 diabetes and be comparable to acarbose, a standard hypoglycemic drug. Also, we suggest that GSE may possess antioxidant activity against the STZ-NA-induced oxidative stress.
Keywords
Gleditschiae Spina; type 2 diabetes; streptozotocin; nicotinamide; OGTT; fasting blood glucose; TRAP;
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