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http://dx.doi.org/10.3746/jkfn.2011.40.10.1411

Effect of Aceriphyllum rossii Ethanol Extract on Lipid Metabolism in Rats Fed a High-Fat Diet  

Park, Yu-Hwa (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services)
Kim, Hee-Yeon (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services)
Lim, Sang-Hyun (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services)
Kim, Kyung-Hee (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services)
Park, Dong-Sik (National Academy of Agricultural Science)
Lee, Jung-Hoon (Dept. of Herbal Crop Research, NIHHIS, RDA)
Park, Chung-Geon (Dept. of Herbal Crop Research, NIHHIS, RDA)
Park, Chung-Berm (Dept. of Herbal Crop Research, NIHHIS, RDA)
Kim, Song-Mun (Dept. of Biological Environment, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.40, no.10, 2011 , pp. 1411-1416 More about this Journal
Abstract
In this study, we investigated the anti-obesity activity of Aceriphyllum rossii ethanol extract on rat fed a high fat diet. Male SD rats were divided into four groups. Group 1 was the control. Group 2 was fed a high-fat diet. Group 3 was the positive control, fed a high-fat diet supplemented with Garcinia Cambogia extracts. Group 4 was fed a high fat diet supplemented with ethanol extracts of Aceriphyllum rossii (EEAR). Precisely 166 mg/kg of powdered Garcinia Cambogia extracts was used for Group 3. Also, 250 mg/kg of EEAR was used for Group 4. The Body weight increased Group 2, but decreased Group 4. The serum total cholesterol in Group 2 increased by 15.26% when compared to Group 1, but only increased 5.29% in Group 3 and 4.29% in Group 4. The liver and mesenteric adipose tissue weights of Group 2 increased compared to Group 1, whereas they decreased in Group 3 and Group 4. As a result of measuring the concentration of triglycerides in extracted livers, Group 2 showed a significant increase compared to the Group 1, and Groups 3 and 4 showed significant decrease compared Group 2. These results suggest that Aceriphyllum rossii ethanol extracts may be useful as an anti-obesity agent.
Keywords
Aceriphyllum rossii; anti-obesity effect; high-fat diet;
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Times Cited By KSCI : 12  (Citation Analysis)
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1 Park PJ, Kim CW, Cho SY, Rha CS, Seo DB, Lee SJ. 2010. Aqueous spray-dried green tea extract regulates body weight and epididymal fat accumulation in mice. Korean J Food Sci Technol 42: 103-108.   과학기술학회마을
2 Smith EB. 1974. The relationship between plasma and tissue lipid in human atherosclerosis. Adv Lipid Res 11: 1-7.
3 De Leo ME, Landriscina M, Palazzotti B, Borrello S, Galeotti T. 1997. Iron modulation of LPS-induced manganese superoxide dismutase gene expression in rat tissues. FEBS Lett 403: 131-135.   DOI
4 Sollof LA, Futenberg HL, Lacko AG. 1973. Serum cholesterol esterification in patients with coronary artery disease. Am Heart J 85: 153-161.   DOI
5 Apfelbaum M, Vague P, Ziegler O, Hanotin C, Thomas F, Leutenegger E. 1999. Long-term maintenance of weight loss after a very low calorie diet: efficacy and tolerability of sibutramine. Am J Med 106: 179-184.   DOI
6 Yum KS. 2001. Orlistat (XenicalR). Korean J Obesity 10: 25-36.   과학기술학회마을
7 Ahn EM, Han JT, Kwon BM, Kim SH, Baek NI. 2008. Anticancer activity of flavonoids from Aceriphyllum rossii. J Korean Soc Appl Biol Chem 51: 309-315.   DOI
8 Lee WC. 1996. Aceriphyllum rossii. In Standard Illustration of Korean Plants. 1st ed. Academy Press, Seoul, Korea. p 147-156.
9 Han JT, Kim HY, Park YD, Lee YH, Lee KR, Kwon BM, Baek NI. 2002. Aceriphyllic acid A, a new ACAT inhibitory triterpenoid from Aceriphyllum rossii. Planta Med 68: 558-561.   DOI
10 Han JT, Bang MH, Chun OK, Kim DO, Lee CY, Baek NI. 2004. Flavonol glycosides from the aerial parts of Aceriphyllum rossii and their antioxidant activities. Arch Pharm Res 27: 390-395.   DOI
11 Min BS, Lee IS, Chang MJ, Yoo JK, Na MK, Hung TM, Thoung PT, Lee JP, Kim JH, Kim JC, Woo MH, Choi JS, Lee HK, Bae KH. 2008. Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway. Planta Med 74: 726-729.   DOI
12 Lee IS, Yoo JK, Na MK, Min BS, Lee JP, Yun BS, Jin WY, Bae KH. 2007. Cytotoxity of triterpenes isolate from Aceriphyllum rossii. Chem Pharm Bull 55: 1376-1378.   DOI
13 Lee CH, Lee JH, Heo CS. 2007. $\beta$-site amyloid precursor protein cleaving enzyme inhibitory activity of Aceriphyllum rossii. Korea Patent 10-2007-0022745.
14 Lee HS, Lee CH, Kim YK, No MC, Park HL, Seo JH, Choi L, Yoo MY. 2008. Metabolic pharmaceutical composition comprising Aceriphyllum rossii extract and active compound isolated from them. Korea Patent 10-2008-0002433.
15 Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. 1998. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord 22: 39-47.   DOI   ScienceOn
16 Ahn IS, Park KY, Do MS. 2007. Weight control mechanisms and antiobesity functional agents. J Korean Soc Food Sci Nutr 36: 503-513.   과학기술학회마을   DOI
17 Rolls BJ, Shide DJ, Thorwart ML, Ulbert JS. 1988. Sibutramine reduces food intake in nondieting women with obesity. Obes Res 6: 1-11.
18 Jeon SM, Choi MS. 2010. Comparison of the effects of cyclodextrin- naringin inclusion complex with naringin on lipid metabolism in mice fed a high-fat diet. J East Asian Soc Dietary Life 20: 20-29.   과학기술학회마을
19 Bray GA. 2004. Medical consequences of obesity. J Clin Endocrinol Metab 89: 2583-2589.   DOI
20 Park JY, Kim JY, Lee SP, Lee JH. 2010. The effect of green coffee bean extract supplementation on body fat reduction in overweight/obese women. Korean J Nutr 43: 374-381.   과학기술학회마을   DOI
21 Hansen DL, Toubro S, Stock MJ, Macdonald IA, Astrup A. 1988. Thermogenic effects of sibutramine in humans. Am J Clin Nutr 68: 1180-1186.
22 Ransac S, Gargouri Y, Moreau H, Verger R. 1991. Inactivation of pancreatic and gastric lipases by tetrahydrolistatin and alkyl-dithio-5-(2-nitrobenzoic acid). A kinetic study with 1,2-didecanoyl-sn-glycerol monolayers. Eur J Biochem 202: 395-400.   DOI
23 Lee JJ, Park MR, Kim AR, Lee MY. 2011. Effects of ramie leaves on improvement of lipid metabolism and anti-obesity effect in rats fed a high fat/high cholesterol diet. Korean J Food Sci Technol 43: 83-90.   과학기술학회마을   DOI
24 Park PJ, Kim CW, Cho SY, Rha CS, Seo DB, Lee SJ. 2010. Aqueous spray-dried green tea extract regulates body weight and epididylmal fat accumulation in mice. Korean J Food Sci Technol 42: 103-108.
25 Kim AR, Lee JJ, Lee YM, Jung HO, Lee MY. 2010. Cholesterol-lowering and anti-obesity effects of Polymnia sonchifolia Poepp. & Endl. powder in rats fed a high fat-high cholesterol diet. J Korean Soc Food Sci Nutr 39: 210-218.   과학기술학회마을   DOI
26 Yoon HJ, Park YS. 2010. Effects of Scutellaria baicalensis water extract on lipid metabolism and antioxidant defense system in rats fed high fat diet. J Korean Soc Food Sci Nutr 39: 219-226.   과학기술학회마을   DOI
27 Reeves PG, Nielson FH, Fahey Jr GC. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
28 Folch J, Less M. 1957. A simple method for the isolation and purification of total lipid from animal tissues. J Biol Chem 226: 497-509.
29 Lee JS, Lee MK, Ha YT, Bok SH, Park HM, Jeong KS, Woo MN, Do GM, Yeo JY, Choi MS. 2006. Supplementation of whole persimmon leaf improves lipid profiles and suppressed body weight gain in rats fed high-fat diet. Food Chem Toxicol 44: 1875-1883.   DOI
30 Hang JY, Choi HJ. 2003. Effects of Artermisia lwayomogi oilgosaccharide on the blood lipids, abdominal adipose tissues, and leptin levels in the obese rats. Korean J Nutr 36: 437-445.