Browse > Article
http://dx.doi.org/10.3746/jkfn.2010.39.4.506

Effects of Medicinal Plant Extract on the Change of Cerebral Hemodynamic in Rats  

Park, Sung-Jin (Dept. of Tourism Food Service Cuisine, Hallym College)
Hahm, Tae-Shik (Dept. of Food and Biotechnology, Hanseo University)
Kim, Cheun-An (Borinara Coperation)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.4, 2010 , pp. 506-510 More about this Journal
Abstract
As an attempt to develop new functional health beverage by using medicinal herb, we investigated the effect of medicinal plant extract (MPE) on mean arterial blood pressure (MABP) and regional cerebral blood flow (rCBF) of rats. The changes of MABP and rCBF were determined by LDF methods. LDF allows for real time, noninvasive, continuous recordings of local CBF. MABP in MPE treated rats showed significant change of MPE 1.0 and 10.0 mg/kg. MPE i.v. administration showed significant increase of rCBF in a dose-dependent manner. Propranolol pretreated MABP showed significant change in the increase of MPE. rCBF of propranolol pretreated rats showed significant change from the i.v. injection concentration of 1.0 and 10.0 mg/kg. The ischemia/reperfusion induced oxidative stress may have contributed to cerebral damage in rats, and the present study provides clear evidence for the beneficial effect of MPE on ischemia induced brain injury. Also, the action mechanism in elevation effect of MPE on rCBF might be concerned with the role of $\beta$-adrenoceptor. The exact component and mechanism remains for the future study.
Keywords
medicinal plant extract; regional cerebral blood flow; blood pressure; food material;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 대한신경외과학회. 1998. 신경외과학. 중앙문화사, 서울. p 150-156.
2 이대희. 2003. 임상신경학(II. 각론). 고려대학교출판부, 서울. p 59-61.
3 이대희. 2003. 임상신경학(II. 각론). 고려대학교출판부, 서울. p 70-77.
4 김기석. 1989. 뇌. 서원사, 서울. p 49-50.
5 성호경. 1996. 생리학. 의학문화사, 서울. p 110.
6 Slomiany BL. 2004. Platelet activation factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase dependent constitutive nitric oxide synthase activation. J Physiol Pharmacol 55: 85-98.
7 오건. 1952. 내과학. 남산당, 서울. p 123-127.
8 이중달. 1990. 그림으로 설명한 병리학. 고려의학, 서울. p 740-743.
9 He J, Klag MJ, Whelton PK, Mo JP, Chen JY, Qian MC, Mo PS, He GQ. 1995. Oats and buckwheat intakes and cardiovascular disease risk factors in an ethnic minority of China. Am J Clin Nutr 61: 366-372.   DOI
10 Son MJ, Cha CG, Park JH, Kim CS, Lee SP. 2005.Manufacture of dropwort extract using brown sugar, fructosesyrup and oilgosaccharides. J Korean Soc Food SciNutr 34: 1485-1489.   과학기술학회마을   DOI
11 Whang TE, Lim HO, Lee JW. 1999. Effect of fermented (Oenanthe javanica D.C.) extract on the activity of enzymes related to liver function of alcohol-administered rats andmice. Kor J Medicinal Crop Sci 7: 107-114.   과학기술학회마을
12 Cho SY, Kim MJ. 1995. The effect of plantafinis semen on serum and hepatic lipid metabolism in fed high and low fat diets. J Korean Soc Food Nutr 24: 517-522.
13 Chung IM, Yun HS, Kim YS, Ahn JW. 1984. Aucubin: potential antidote for $\alpha$-amanitin poisoning. J Toxicol Clin Toxicol 22: 77-85.   DOI
14 Carlo B, Fabio D. 1982. Assignment of correct structure to two tetra-hydrodideoxy aucubins. J Org Chem 147: 1343-1352.
15 Han SM. 2005. Studies on the functional components and cooking aptitude for medicinal tea of Chrysnathemum indicum L. PhD Dissertation. Sejong University, Seoul, Korea. p 1.
16 Shin GC, Shin YC. 1992. New our talk large a dictionary. Samsung publishing Co., Seoul, Korea. p 68.
17 Choi YJ. 1992. Korea folk vegetation. Academy books, Seoul, Korea. p 53.
18 신민교. 1997. 임상본초학. 영림사, 서울.
19 Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. 1986.A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17: 738-743.   DOI   ScienceOn
20 Lee HY, Yoo MJ, Chung HJ. 2001. Antibacterial activities in watercress (Oenanthe javanica D.C.) cultivated with differentculture methods. Kor J Food Culture 16: 243-249.   과학기술학회마을