Browse > Article
http://dx.doi.org/10.3746/jkfn.2009.38.2.142

Anticancer Activity on Ethanolic Extract of the Masou Salmon (Oncorhynchus masou) in vitro and in vivo  

Oh, Hyun-Taek (Dept. of Food Science and Biotechnology, Division of Biotechnology, School of Bioscience and Biotechnology, Kangwon National University)
Chung, Mi-Ja (The Nutraceutical Bio Brain Korea 21 Project Group, Kangwon National University)
Ham, Seung-Shi (Dept. of Food Science and Biotechnology, Division of Biotechnology, School of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.2, 2009 , pp. 142-145 More about this Journal
Abstract
The cytotoxic activity against human cancer cells and anti-tumor effect in Balb/c mice of a 70% ethanol extract from masou salmon (MSE) was investigated. The cancer cell lines including human breast adenocarcinoma (MCF-7), human lung carcinoma (A549), human hepatoblastoma (HepG2), human gastric carcinoma (AGS), human cervical adenocarcinoma (HeLa) and transformed primary human embryonal kidney (293) exposed to MSE decreased cell viability as indicated by the MTT assay. The MSE shows significant cytotoxicity on MCF-7, A549, HepG2, AGS and HeLa cells, and are more active than 293 cells. The treatment with 1 mg/mL MSE resulted in 9.2%, 12.7%, 16.6%, and 16.9% cell survival against A549, MCF-7, HepG2, and AGS cells, respectively. Moreover, anticancer effect in vivo of MSE was tested in the animal system using Balb/c mice transplanted sarcoma-180 cells. MSE showed inhibition of tumor growth and the rate of inhibition was 44.7% and 55.7% at the 25 mg/kg body weight and 250 mg/kg body weight, respectively. Thus, we suggest that MSE could be a beneficial material for human cancer prevention.
Keywords
Oncorhynchus masou; cytotoxicity; antitumor effects;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Choi JW, Ryu DY, Kim YK, Hong EG, Kwun MS, Han JS. 2000. Extraction and purification of bioactive materials from Agaricus blazei fruition bodies. Korean J Biotechnol Bioeng 15: 293-298   과학기술학회마을
2 Oh HT, Kim SH, Choi HJ, Chung MJ, Ham SS. 2008. Antioxidative and antimutagenic activities of 70% ethanol extract from masou salmon (Oncorhynchus masou). Toxicol in Vitro 22: 1484-1488   DOI   ScienceOn
3 Chung MJ, Walker PA, Brown RW, Hogstrand C. 2005. ZINC-mediated gene expression offers protection against $H_2O_2$-induced cytotoxicity. Toxicol Appl Pharmacol 205: 225-236   DOI   ScienceOn
4 Mori T. 1934. On the geographical distribution of Korean Salmonidae. Proc Fifth Pac Sci Kong (Canada, 1933) 5: 3775-3793
5 Kang YJ. 1974. A study on the racial classification of Asian chum, Oncorhynchus keta (Walbaum) based on scale characteristics. Bull Korean Fish Soc 7: 91-97   과학기술학회마을
6 Myoung JG, Kim YU. 1993. Morphological study of Oncorhynchus spp. (Pisces: Salmonidae) in Korea-IV-Comparison of morphological characters of chum salmon Oncorhynchus keta, masu salmon, Oncorhynchus masou and rainbow trout Oncorhynchus mykiss. Korean J Ichthyol 5: 96-112
7 이종례. 1991. 한.영.일 수산물 식물영사전. 현대해양사, 서울. p 112
8 최기철. 1993. 우리 민물고기 백가지. 현암사, 서울. p 484-487
9 김인배. 1974. 한국산 담수어류. 태화출판사, 서울. p 40-41
10 Ham SS, Oh HT, Kim SH, Yoo SJ. 2007. The antimutagenic effects and cytotoxic activities of Agaricus blazei murill mycelium extracts and fractions. J East Asian Soc Dietary Life 17: 563-570   과학기술학회마을
11 Oberley TD, Oberley LW. 1997. Antioxidant enzyme levels in cancer. Histol Histopathol 12: 525-535
12 Kim HT, Kim JW, Lim MK, Jin TW, Yeo SG, Jang KH, Oh TH, Lee KW. 2007. Cytotoxic effect of Artemisia capillaris extracts on the cancer cells on in vitro. J Vet Clin 24: 367-371   과학기술학회마을
13 Kim HT, Kim JW, Jin TW, Kim JE, Lim MK, Yeo SG, Jang KH, Oh TH, Lee KW. 2007. Effects of blood biochemistry and tumors' weights of Artemisia capillaris methanol extract in mice bearing cancer cells. J Vet Clin 24: 372-378   과학기술학회마을
14 Lee YS, Kim DS, Ryu BH, Lee SH. 1992. Antitumor and immunomodulating effects of seaweeds toward sarcoma-180 cell. J Korean Soc Food Nutr 21: 544-550   과학기술학회마을
15 Baek SH, Kim SY, Geong KI, Kweon MJ, Choi OS, Kim JH, Kim HS, Ha BS. 1999. Comparison of carotenoid pigments in Korean bittering, Cheilognathus signifier and bride bittering, Rhodeus ukekii in the subfamily cyprinidae. J Korean Soc Food Sci Nutr 28: 1220-1225   과학기술학회마을
16 Slaga TJ. 1995. Inhibition of the induction of cancer by antioxidants. Adv Exp Med Biol 369: 167-174   DOI
17 Ha BS, Baek SH, Kim SY. 2000. Carotenoids components of tunicate, shellfish and its inhibitory effects on mutagenicity and growth of tumor cell. J Korean Soc Food Sci Nutr 29: 922-934   과학기술학회마을
18 Kim GH, Han HK. 1998. The effect of mushroom extracts on carbon tetrachloride induced hepatotoxicity in rats. J Korean Soc Food Sci Nutr 27: 326-332   과학기술학회마을
19 Oh HT, Kim SH, Yoo SJ, Choi HJ, Chung MJ, Ham SS. 2008. Component analysis of masou salmon (Oncorhynchus masou). J Korean Soc Food Sci Nutr 37: 886-890   과학기술학회마을   DOI   ScienceOn
20 Ham SS, Kim SH, Yoo SJ, Oh HT, Choi HJ, Chung MJ. 2008. Antimutagenicity and cytotoxic effects of methanol extract from deep sea water salt and sea tangle added soybean paste (Doenjang). J Korean Soc Food Sci Nutr 37: 416-421   과학기술학회마을   DOI   ScienceOn