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http://dx.doi.org/10.13103/JFHS.2018.33.5.383

Immunomodulation by Bioprocessed Polysaccharides from Lentinus edodes Mycelia Cultures with Rice Bran in the Salmonella Gallinarum-infected Chicken Macrophages  

Lee, Hyung Tae (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University)
Lee, Sang Jong (STR Biotech, Ltd.)
Yoon, Jang Won (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University)
Publication Information
Journal of Food Hygiene and Safety / v.33, no.5, 2018 , pp. 383-388 More about this Journal
Abstract
In this study, we investigated the effect of bioprocessed polysaccharides (BPPs) from liquid culture of Lentinus edodes fungal mycelia containing rice bran (BPP-RB) on a chicken-derived macrophage cell line, HD-11, when infected with Salmonella Gallinarum, an etiological agent of fowl typhoid. Experimental results demonstrated water extract of BPP-RB did not show growth inhibitory effects on S. Gallinarum 277. Protein expression profiles were also not altered by its treatment. Nonetheless, it could (i) enhance phagocytic activity of HD-11 cells, (ii) activate transcriptional expression of Th1-type cytokines such as tumor necrosis factor-${\alpha}$ and interleukin $(IL)-1{\beta}$, iNOS, as well as an immunosuppressive cytokine IL-10, and (iii) negatively regulate Th2-type cytokines such as IL-4 and IL-6. Together results suggest that BPP-RB may be applicable for preventing fowl typhoid or other Salmonella infections in poultry farms as a potential feed additive.
Keywords
Rice bran; Salmonella Gallinarum; Chicken macrophage; Immunomodulation;
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