Browse > Article
http://dx.doi.org/10.13103/JFHS.2017.32.3.187

Preliminary Monitoring of Mycotoxins for Safety Management of Medicinal Herbs  

Lee, Hyun-Kyung (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Kim, Ae-Kyeong (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Kim, Ouk-Hee (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Kim, Sung-Dan (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Lee, Young-Ju (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Lee, Sea-Ram (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Kim, Il-Young (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Lee, Jung-Mi (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Yu, In-Sil (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Jung, Kweon (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
Publication Information
Journal of Food Hygiene and Safety / v.32, no.3, 2017 , pp. 187-192 More about this Journal
Abstract
The consumption of herbal medicines has been increasing with growing interest in health. However, due to recent climate change and the complex distribution process of herbal medicines with high import dependence the likelihood of contamination with mycotoxin has been increased. Mycotoxins are emerging as key indicators for ensuring safety of herbal medicines. A total of 498 herbal medicine samples were screened for mycotoxin contamination in this study. Aflatoxin in the herbal medicine samples was extracted by using immunoaffinity column, then the extracted aflatoxin was quantified via high performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) method. The extraction method was verified by linearity, recovery, LOD and LOQ. Aflatoxins were detected in 39/498 samples in an average of $7.670{\mu}g/kg$ ($0.610-77.452{\mu}g/kg$ range). Although safety standards for Corydalis Tuber is not currently available in korea, five of the 39 samples had high concentration of aflatoxins (average of $14.9{\pm}4.1{\mu}g/kg$). In conclusion, it is urgent to establish safety criteria of aflatoxin in Corydalis Tuber. The results of the current study suggest that continuous monitoring is necessary for proactive management of herbal medicine safety.
Keywords
Herbal medicines; HPLC-FLD; Aflatoxin; Corydalis Tuber;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Ryu, J. G., Lee, S., Lee, S. H., Nam, Y. J., Kim, M., Lee, T., & Yun, J. C.: Natural Occurrence of Fusarium Head Blight and Its Mycotoxins in 2010-harvested Barley and Wheat Grains in Korea. Res. Plant Dis., 17, 272-279 (2011).   DOI
2 Lee, S. H., Son, S. W., Nam, Y. J., Shin, J. Y., Lee, S. H., Kim, M. J., & Lee, T.: Natural Occurrence of Fusarium Mycotoxins in Field-collected Maize and Rice in Korea in 2009. Res. Plant Dis., 16, 306-311 (2010).   DOI
3 Lee, S., Park, K., Chun, H. S.: Risk prediction of mycotoxin aflatoxin B1 according to climate change scenarios in Europe. Safe Food, 7, 60-70 (2012).
4 Smith, J. E., & Moss, M. O.: Mycotoxins. Formation, analysis and significance. John Wiley & Sons Ltd. (1985).
5 Suh, J. H., Sho, Y. S., Park, S. S., Choi, W. J., Lee, J. O., Kim, H. Y., ... & Oh, K. S.: Exposure assessment of total aflatoxin in foods. Korean J. Food Sci. Technol., 39, 25-28 (2007).
6 Park, M. J., Yun, M. H., Hong, H. K., Joe, T. S., Lee, I. S., Park, J. H., Ko, H. U.: Investigation of aflatoxin contamination in food. J. Food Hyg. Saf., 23, 108-112 (2008).
7 Kang, Y. W., Cho, T. Y., Food, D. R. K., Park, H. R., Oh, K. S., Kim, D. S.: Analysis of total aflatoxins in spices and dried fruits. J. Food Hyg. Saf., 25, 65-72 (2010).
8 Sun, T. T., Chu, Y. Y.: Carcinogenesis and prevention strategy of liver cancer in areas of prevalence. Journal of Cellular Physiology, 121, 39-44 (1984).   DOI
9 Peers, F., Bosch, X., Kaldor, J., Linsell, A., Pluijmen, M.: Aflatoxin exposure, hepatitis B virus infection and liver cancer in Swaziland. Int. J. Cancer., 39, 545-553 (1987).   DOI
10 International Agency for Research on Cancer.: Overall evaluations of carcinogenicity: an update of IARC monographs volumes 1 to 42. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (1987).
11 World Health Organization, & International Agency for Research on Cancer.: Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 56 (1993).
12 Wang, J. S., & Groopman, J. D.: DNA damage by mycotoxins. Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 424, 167-181 (1999).   DOI
13 Lee, J. T.: A Study on the Current Status of Korean Herbal Medicines. Ministry of Food and Drug Safety. 91-1 (2006).
14 Food standards and specifications. Ministry of Food and Drug Safety. (Notice 2015-78).
15 Food standards and specifications. Korea Pharmacopoeia. (Notice 2016-57).