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http://dx.doi.org/10.13103/JFHS.2017.32.1.70

Anti-cancer Effect of Marine Resources Against Human Colorectal Cancer Cells  

Jung, Joohee (College of Pharmacy, Duksung Women's University)
Publication Information
Journal of Food Hygiene and Safety / v.32, no.1, 2017 , pp. 70-74 More about this Journal
Abstract
Recently, the area of marine resources has become concerned with sources for the next generation of the bio-industry. Until present, development of the marine resources has remained limited, although a large number of these resources are considered to have potential for various significant biological activities. Most marine sponges, marine algae and coral could be used to create specific compounds for survival against a harsh environment. Therefore, it was necessary that these materials needed to be elucidated with biological activities, such as like anti-inflammatory, anti-viral or anti-cancer effects for their utilization in the bio-industry. In this study, we screened extracts of marine resources for their anti-cancer effect on human colorectal cancer cells. These resources were collected at Kosrae of Micronesia on April, 2013 and extracted with methanol. Cytotoxicity of marine resources was observed. Of a total of 20 specimens, three specimens dose-dependently demonstration inhibition of cell viability. Furthermore, cells treated with these specimens for 48h were induced p53, p21, Bax and caspase-3. The results suggest that they involved p53-mediated apoptosis. Two positive specimens (1304KO-327 and 1304KO-329) were verified as the identical materials, which are Hyrtios sp. Unfortunately 1304KO-207 was not yet classified and needed to identify in the further study. There results suggested that marine resources with positive potential in anticancer effect would be good candidates as useful bio-resources.
Keywords
Colorectal cancer cell; Cytotoxicity; Marine resources; Screening;
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1 Malve H.: Exploring the ocean for new drug developments: Marine pharmacology. J. Pharm. Bioallied Sci. 8, 83-91 (2016).   DOI
2 Ruocco N., Costantini S., Guariniello S., Costantini M.: Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential. Molecules, 21 (2016).
3 Xu L., Meng W., Cao C., Wang J., Shan W., Wang Q.: Antibacterial and antifungal compounds from marine fungi. Mar. Drugs, 13, 3479-3513 (2015).   DOI
4 Su Y.D., Su T.R., Wen Z.H., Hwang T.L., Fang L.S., Chen J.J., Wu Y.C., Sheu J.H., Sung P.J.: Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae). Mar. Drugs, 13, 1037-1050 (2015).   DOI
5 Su Y.D., Wu T.Y., Wen Z.H., Su C.C., Chen Y.H., Chang Y.C., Wu Y.C., Sheu J.H., Sung P.J.: Briarenolides U-Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Mar. Drugs, 13, 7138-7149 (2015).   DOI
6 Tian Y.Q., Lin X.P., Wang Z., Zhou X.F., Qin X.C., Kaliyaperumal K., Zhang T.Y., Tu Z.C., Liu Y.: Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40. Molecules, 21, E34 (2015).   DOI
7 Wang J., Wei X., Qin X., Tian X., Liao L., Li K., Zhou X., Yang X., Wang F., Zhang T., Tu Z., Chen B., Liu Y.: Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702. J. Nat. Prod. 79, 59-65 (2016).   DOI
8 Ruiz-Ruiz F.M., Mancera-Andrade E.I., Iqbal H.M.: Marine-Derived Bioactive Peptides for Biomedical Sectors - A Review. Protein Pept. Lett. (2016).
9 Eo H.J., Kwon T.H., Park G.H., Song H.M., Lee S.J., Park N.H., Jeong J.B.: In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells. Mar. Drugs, 14 (2016).
10 Senthilkumar K., Kim S.K.: Anticancer effects of fucoidan. Adv. Food Nutr. Res. 72, 195-213 (2014).
11 Hanahan D., Weinberg R.A.: Hallmarks of cancer: the next generation. Cell, 144, 646-674 (2011).   DOI
12 Oh C.M., Won Y.J., Jung K.W., Kong H.J., Cho H., Lee J.K., Lee D.H., Lee K.H.: Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013. Cancer Res. Treat. 48, 436-450 (2016).   DOI
13 Gartel A.L., Tyner A.L.: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 1, 639-649 (2002)
14 Bae W., Lim H.K., Kim K.M., Cho H., Lee S.Y., Jeong C.S., Lee H.S., Jung J.: Apoptosis-Inducing Activity of Marine Sponge Haliclona sp. Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells. Evid. Based Complement. Alternat. Med. 2015, 717959 (2015).
15 Choi K.H., Jung J.: Anti-poliferation effect of Coscinoderma sp. extract on human colon cancer cells. J. Food Hyg. Saf. 31(4), 294-298 (2016).   DOI
16 Chiocca E. A.: Oncolytic viruses, Nat. Rev. Cancer, 2, 938-950 (2002).   DOI
17 Nakano K., Vousden K.H.: PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell, 7(3), 683-694 (2001).   DOI
18 Mlynarczyk C., Fahraeus R.: Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nat. Commun. 5:5067, 1-16 (2014).
19 Yu Z., Wang H., Zhang L., Tang A., Zhai Q., Wen J., Yao L., Li P.: Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression. Biochem. Biophy. Res. Comm. 386, 607-611 (2009).   DOI
20 Hemann M.T., Lowe S.W.: The p53-Bcl-2 connection. Cell Death Differ. 13, 1256-1259 (2006).   DOI
21 Lim H.K., Bae W., Lee H.S., Jung J.: Anticancer activity of marine sponge Hyrtios sp. extract in human colorectal carcinoma RKO cells with different p53 status. BioMed Res. Int. 2014, 413575 (2014).
22 Koh S.I., Shin H.S.: The anti-rotaviral and anti-inflammatory effects of Hyrtios and haliclona species. Microbiol. Biotechnol. Jul (2016).
23 Wu S.Y., Sung P.J., Chang Y.L., Pan S.L., Teng C.M.: Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells. BioMed Res. Int. 2015, 738241 (2015).
24 Al-Massarani S.M., El-Gamal A.A., Al-Said M.S., Abdel-Kader M.S., Ashour A.E., Kumar A., Abdel-Mageed W.M., Al-Rehaily A.J., Ghabbour H.A., Fun H.K.: Studies on the Red Sea Sponge Haliclona sp. for its Chemical and Cytotoxic Properties. Pharmacog. Mag. 12, 114-119 (2016).   DOI