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http://dx.doi.org/10.13103/JFHS.2016.31.2.107

Genotoxicity Study from the Extracts of Fermented Acanthopanax koreanum  

Cho, Myounglae (Department of Food science and Biotechnology, Kangwon National University)
Kim, Young-Hyun (Department of Food science and Biotechnology, Kangwon National University)
Kim, Jae-Min (Department of Food science and Biotechnology, Kangwon National University)
Lee, Sang-Jong (STR Biotech Co., LTD.)
Shin, Hyun Mu (University of Massachusetts Medical School)
Lee, Ok-Hwan (Department of Food science and Biotechnology, Kangwon National University)
Publication Information
Journal of Food Hygiene and Safety / v.31, no.2, 2016 , pp. 107-112 More about this Journal
Abstract
This study was to determine genotoxicity from the extracts of fermented Acanthopanax koreanum. The bacterial reverse mutation assay, the extracts of fermented A. koreanum did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA with or without metabolic activation of S-9 mixture. In addition, the micronucleus formation in ICR mice, the extracts of fermented A. koreanum treated with dose of 500, 1,000 and 2,000 mg/kg did not affected micronucleated polychromatic erythrocytes (MNPCE/2,000 PCE) and polychromatic erythrocytes (PCE)/200 polychromatic erythrocyte+normochromatic erythrocyte (RBC). The cytotoxicity effects using CHO-K1 cells observed no significant changes compared with negative control group (p < 0.05). Moreover, the extracts of fermented A. koreanum did not cause a significant chromosome aberration on CHO-K1 cells in the chromosome aberration assay. Therefore, these results suggest that the extracts of fermented A. koreanum did not induce any harmful genotoxic effects.
Keywords
fermented Acanthopanax koreanum; genotoxicity; bacterial reverse mutation; micronucleus formation; chromosome aberration;
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Times Cited By KSCI : 9  (Citation Analysis)
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