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http://dx.doi.org/10.13103/JFHS.2015.30.3.258

The Antioxidant and Skin Whitening Effect of Withania somnifera (Winter Cherry)  

Kim, Dae Yong (Department of Pharmaceutical Science and Engineering, Seowon University)
Kim, Mee Kyung (Department of Cosmetic Science & Technology, Seowon University)
Kim, Bong-Woo (Department of Cosmetic Science & Technology, Seowon University)
Publication Information
Journal of Food Hygiene and Safety / v.30, no.3, 2015 , pp. 258-264 More about this Journal
Abstract
Withania somnifera has been used in folk medicine to treat various ailments for centuries. In this studies to investigate the whitening effect of Withania somnifera extracts as an active ingredient for whitening cosmetics, the antioxidant capacity and the effects of Withania somnifera extracts on melanogenesis in B16-F10 melanoma cells were identified. Withania somnifera extracts significantly reduced both tyrosinase activity and melanin content in a concentration-dependent manner. Furthermore, it was found that Withania somnifera extracts decreased ${\alpha}-MSH$ (melanocyte-stimulating hormone)-induced tyrosinase activity and MITF(microphthalmia associated transcription factor) protein expression. These data indicate that Withania somnifera extracts attenuate ${\alpha}$-MSH-stimulated melanin synthesis by modulating MITF expression and that they may be a useful therapeutic agent for treating hyperpigmentation and an ingredient of whitening cosmetics.
Keywords
Withania somnifera; whitening; melanocyte; tyrosinase;
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