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http://dx.doi.org/10.13103/JFHS.2015.30.1.120

Effect of Repeated MSG Administration on Cognitive Ability and Anxiety of Juvenile Rats  

Lee, Hae-Nim (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Choo, Gang-Sik (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Shin, Seong-Ah (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Park, Jung-Joon (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Lee, Se-Geun (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Kim, Se-Woon (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Kim, Hyun-Sun (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Lee, Song-Hee (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Lim, Jeong-Min (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Kim, Hyeong-Jin (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Park, Young-Seok (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Kim, Sang-Ki (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Park, Byung-Kwon (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Kim, Byeong-Soo (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Jung, Ji-Youn (Dept. of Companion and Laboratory Animal Science, Kongju National University)
Publication Information
Journal of Food Hygiene and Safety / v.30, no.1, 2015 , pp. 120-125 More about this Journal
Abstract
The objective of this study is to investigate the effect of MSG on cognitive function and anxiety by the T-maze and elevated-plus-maze test and repeated oral dose toxicity in SD rat of MSG. The rats were treated with MSG of control group, low group (3 g/kg) and high group (5 g/kg) intragastrically for 4 weeks, respectively. We examined the body weight, the clinical signs, T-maze, Elevated-plus-maze, hematological analysis and serum biochemical analysis, we also observed the histopathological changes of liver, kidney in rats. No significant differences in body weights, biochemical analysis and histopathological observations between control and MSG treatment group were found. In the elevated plus maze (EPM), MSG-treatment group has more open arm visited than controls. MSG-treatment group has been more activated in T-maze test. These data indicate the continuous high MSG intake could be increased the anxiety and could be decreased cognitive ability. In conclusion, MSG is physiologically safety, but high MSG intake could be increased the anxiety and could be decreased cognitive ability in juvenile rat.
Keywords
Juvenile rats; MSG;
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  • Reference
1 DH Kim, KH Yang : Effects of Monosodium Glutamate on unscheduled DNA synthesis and DNA Single-Strand breaks in primary cultures of rat hepatocytes, Korean Environmental Mutagen Society, 7(2), 65-71 (1987).
2 GB Kauffman : The monosodium glutamate story:the commercial production of MSG and other amino acids. J. Chem. Educ, 81(3), 347 (2004).   DOI
3 Walker R and Lupien JR : The safety evaluation of monosodium glutamate. The Journal of nutrition, 130.4, 1049S-1052S (2000).
4 Freeman M : Reconsidering the effects of monosodium glutamate: a literature review. J Am Acad Nurse Pract, 18(10), 482-486 (2006).   DOI
5 Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, Kempski O, Stehle P, Steinhart H, Walker R : Consensus meeting: monosodium glutamate-an update. Eur Jclin Nutr, 61(3), 304-313 (2007).   DOI
6 Blaycock R : Excitotoxins-the taste that kills, Health Press, p8 (1996).
7 Nagata M, Suzuki W, Iizuka S, Tabuchi M, Maruyama H, Takeda S, Aburada M, Miyamoto K : Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate. Exp Anim, 55(2), 109-115 (2006).   DOI
8 Vorob'ev VV : Effects of food supplements on the safety and quality of seafoods. Gig Sanit, 1, 51-54 (2007).
9 Olney JW : Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science, 164(3880), 719-721 (1969).   DOI
10 Olney JW, Sharpe LG : Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science, 166(3903), 386-388 (1969).   DOI
11 Trentini GP, Botticelli A, Botticelli CS : Effect of monosodium glutamate on the endocrine glands and on the reproductive function of the rat. Fertil Steril, 25(6), 478-83 (1974).
12 Allen DH, Delohery J, Baker G : Monosodium L-glutamateinduced asthma. Joumal of allergy and clinical immunology, 80(4), 530-537 (1987).   DOI
13 Jacobson LH, Bettler B, Kaupmann K, Cryan JF : Behavioral evaluation of mice deficient in GABAB (1) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology, 190, 541-553 (2007).   DOI