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http://dx.doi.org/10.13103/JFHS.2014.29.2.092

Monitoring of Fake Anti-impotence Drugs  

Kim, Beom-Ho (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Jeon, Jong-Sup (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Lee, Myung-Jin (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Park, Eun-Mi (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Cho, Sang-Hun (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Kwon, Hye-Jung (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Yoon, Mi-Hye (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Lee, Jong-Bok (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
Publication Information
Journal of Food Hygiene and Safety / v.29, no.2, 2014 , pp. 92-98 More about this Journal
Abstract
The safety of fake anti-impotence drugs (fake Viagra : 26 samples, fake Cialis : 25 samples) distributed in Gyeonggi province was studied by monitoring the concentrations of anti-impotence pharmaceutical ingredient and their analogues. The concentrations of anti-impotence pharmaceutical ingredient 4 specis and their analogues 17 specis were estimated using by HPLC/PDA, LC-MS/MS. The range of concentration of sildenafil in fake viagra was 40~199 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 65%. 3 cases in tested samples contained sildenafil and tadalafil. The range of concentration of sildenafil in fake cialis was 102~249 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 88%. One case in tested samples contained demethylhongdenafil (90 mg/tablet). These results indicate that there were many fake anti-impotence drug contained high level of anti-impotence pharmaceutical ingredients, a sustainable monitoring and the blocked distribution of fake anti-impotence drugs recommended.
Keywords
fake anti-impotence drugs; sildenafil; tadalafil; demethylhongdenafil;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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1 Lee HS, Lee JG, Kim JC, Oh JH, Jang YM. and Kim MH., Korean J. Food Sci. Technol. 40, 675-682 (2011).
2 Y. J. Yang, D. M. Song, W. M. Jiang, Rapid Resolution RPHPLC- DAD Method for Simutaneous Determination of Sildenafil, Vadenafil, Tadalafil in pharmacetical Preparations and Counterfeit Drugs. Analytical Letters., 43(3), 373-380 (2010).   DOI
3 Myung SW, Park SH. and Cho HW. Analysis of sildenafil and its analogues by LC/MS/MS. Anal. Sci. Technol. 16, 488-198 (2003).
4 Hong HG, Bang SJ, Park KH, Lee IS, Park JH and Kim JC. A Study on Contents of Anti-impotence drug/drug-like compounds in Food. Koren J. Sanitation. 22(3), 89-96 (2007).
5 Jang JH, Park KS, Park HK, Koo YE, Choi YJ, Hwang IK. and Kim DB. imultaneous identification/determination system for sildenafil, homosildenafil, vardenafil, and tadalafil as adulterants in foods. J. Fd. Hyg. Safety. 18, 195-201 (2003).
6 Korea Food & Drug Administration, http://www.kfda.go.kr/ seoul/index.kfda? mid=26&seq=4585&cmd=v.
7 KFDA, The Korean pharmacoepia, 9th Ed., Korea Food & Drug Administration, Seoul, Korea, 2007.
8 KFDA, Anti-impotence drug and their analogues, Korea Food & Drug Administration, Seoul, Korea, 2004.
9 Seo WI, Kang PM, Kim HM, Chun JY, Um JD and Min KS. A Suvey of Understanding of Viagra in primary Physician and Gneral Population.. Koren J Androl. 27(2), 103 (2007).
10 Kim MS, Myung SC. and Kim SC. Perceptions of erectile dysfuntion treatment of patients visiting university hospital in the era of multiple oral agents. Koren J Androl. 24, 18-22 (2006).
11 Boyce EG, Umland EM. Sildenafil citrate: A therapeutic update. Clinical Therapeutics. 23, 2-23 (2001).   DOI   ScienceOn
12 Choi DM.. Structure elucidation and determination of illegal compound (Anti-impotance drug analogues) in foods. Anal. Sci. Technol. 21(2), 65-83 (2008).
13 KFDA, 'Korean Food Standards Codex', Korea Food & Drug Administration, Seoul, Korea, 2010.
14 Choi DM, Im MH, Lee KJ, Kwon KI, Jeong JY, Park GS, Hong MK and Lee CW. Determination anti-impotence druglike compounds in food. Anal. Sci. Technol. 17, 520-526 (2004).
15 KISTI, Erectile Dysfunction, Korea Institute of Science and Technology Information, Seoul, Korea, 2003.