Browse > Article
http://dx.doi.org/10.13103/JFHS.2013.28.4.367

Effects of Kalopanax Pictus Extracts and Their Related Origin on Gastric Lesions  

Hwang, In Young (College of Pharmacy, Duksung Women's University)
Hwang, Seon A (College of Pharmacy, Duksung Women's University)
Jeong, Choon Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Journal of Food Hygiene and Safety / v.28, no.4, 2013 , pp. 367-375 More about this Journal
Abstract
Kalopanax pictus has pharmacologically anti-inflammatory and analgesic effect and is known to respond to treatment of backache, knee pain and etc. In this study, we investigated the effects on gastric lesions of Kalopanax pictus both from Korea (KPK) and China (KPC) compared with their related origin, Znthoxylum ailanthoide both from Korea (ZAK) and China (ZAC), and Korean Bombax malabaricum (BMK). In preliminary screening, KPK and KPC shown effective inhibition of HCI EtOH-induced gastritis in rats. To elucidate their protective effects on gastric lesions, we assessed inhibition of H. pylori colonization, 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging activities, reducing power test, and inhibition of lipid peroxidation. KPK was the most effective from antioxidant assays. KPK also shown the inhibition of indomethacin-induced gastric ulcer in rats. Gastric secretion in rats, KPK reduced the secretion of gastric juice and total acidity and raised pH. Therefore, it is possible that KPK can be developed as health functional food and natural medicine. In addition, it can contribute to the standardization with objectivity and reliability for KPK through the criteria establishment of the precise origin of medicine, the prevention of indiscriminate distribution of imitation, and the rising rate of dependence on imports of medicinal herbs, and mixing prevention of low-quality goods.
Keywords
Kalopanaxpictus; gastritis; gastric ulcer; anti-oxidant; H.pylori;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Shay, H. and Komarov, S.A., Fels, S.S. and Meranze, D.: A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol., 4, 43-61 (1945).
2 Behera, B.C., Adawadkar, B. and Makhija, U.: Inhibitory activity of xanthine oxidase and superoxide-scavenging activity in some taxa of the lichen family Graphidaceae. Phytomed., 10, 536-543 (2003).   DOI   ScienceOn
3 Lee, E.B., Li, D.W., Hyun, J.E., Kim, I.H. and Whang, W.K.: Anti-inflammatory activity of methanol extract of Kalopanax pictus bark and its fractions. J. Ethnopharmacol., 77, 197-201 (2001).   DOI   ScienceOn
4 생약학교재편찬위원회: 생약학. 동명사, 경기, pp. 549 (2006).
5 Massimo, R. and Robert, M.G.: Staging and grading of chronic gastritis. Human Pathol., 36, 228-233 (2005).   DOI   ScienceOn
6 Long, L.H., Evans, P.J. and Halliwell, B.: Hydrogen peroxide in human urine: implications for antioxidant defense and redox regulation. Biochem. Biophys. Res. Commun., 263, 605-609 (1999).
7 Nishimiki, M., Rao, N.A., Appaji, N. and Yagi, K.: The occurrence of superoxide anion in the reaction of reduced henazine methosulfate and molecular oxygen. Biochem. Biophys. Res. Commun., 46, 849-854 (1972).   DOI   ScienceOn
8 Subhashinee, S., Wijeratne, K., Susan, L. and Vicky, S.: Hydrogen peroxide induced oxidative stress damage and antioxidant enzyme response in caco-2 human colon cells. J. Agric. Food Chem., 53, 8768-8774 (2005).   DOI   ScienceOn
9 Kim, J.M., Shin, J.E., Han, M.J., Baek, N.I. and Kim, D.H.: Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori. Natural Product Sciences, 9, 158-160 (2003).
10 Kasuya, Y., Urushidani, T. and Okabe, S.: Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat. Jpn. J. Pharmacol., 29, 670-673 (1979).   DOI
11 Bang, S.Y., Park, G.Y., Park, S.Y., Kim, J.H., Lee, Y.K., Lee, S.J. and Kim, Y.: The stem bark of Kalopanax pictus exhibits anti-inflammatory effect through heme oxygenase-1 induction and NF-${\kappa}B$ suppression. Immune Netw., 10, 212-218 (2010).   DOI   ScienceOn
12 Warren, J.S., Kunkel, S.L., Cunningham, T.W., Johnson, K.J. and Ward, P.A.: Macrophage-derived cytokines amplify immune complex-triggered $O^{2-}$. responses by rat alveolar macrophages. Am. J. Pathol., 130, 489-495 (1988).
13 Yoshikawa, T., Takemura, T., Seto, O., Tanigawa, T., Tainaka, K., Morita, Y., Yoshida, N., Sugino, S. and Kondo, M.: Role of lipid peroxidation and polymorphonuclear leukocytes-derived oxygen radicals in acute gastric lesions induced by hyperthermic treatment. Nihon Shokakibyo Gakkai Zasshi, 86, 159-164 (1989).
14 Itoh, M. and Guth, P.H.: Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology, 88, 1162-1167 (1985).   DOI
15 Mizui, T. and Dodeuchi, M.: Effect of polyamines on acidified EtOH induced gastric lesion in rats. Jpn. J. Pharmacol., 33, 939-945 (1983).   DOI
16 Bae, E.A., Han, M.J., Baek, N.I. and Kim, D.H.: In vitro anti Helicobacter pylori activity of panaxtriol isolated from ginseng. Arch. Pharm. Res., 24, 297-299 (2001).   DOI   ScienceOn
17 Nishimiki, M. Rao, N.A., Appaji, N. and Yagi, K.: The occurrence of superoxide anion in the reaction of reduced henazine methosulfate and molecular oxygen. Biochem. Biophys. Res. Commun., 46, 849-854 (1972).   DOI   ScienceOn
18 Uchiyama, M., Suzuki, Y. and Fukuzawa, K.: Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi, 88, 678-683 (1968).
19 Oyaizu, M.: Studied on products of browning reaction; antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr., 44, 307-315 (1986).   DOI
20 Koleva, I.I., Beek, T.A., Linssen, J.P.H., Groot, A. and Evastatieva, L.N.: Screening of plant extracts for antioxidant activity; a comparative study on three testing methods. Phytochem. Anal., 13, 8-17 (2002).   DOI   ScienceOn
21 Choi, C.H., Cha, Y.J., An, C.S., Kim, K.J., Kim, K.C., Moon, S.P., Lee, Z.H. and Min, Y.D.: Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein. Cancer Cell Int., 4, 6-17 (2004).   DOI   ScienceOn
22 Hu, W., Lee, S.K., Jung, M.J., Heo, S.I., Hur, J.H. and Wang, M.H.: Induction of cell cycle arrest and apoptosis by the ethyl acetate fraction of Kalopanax pictus leaves in human colon cancer cells. Bioresour. Technol., 101, 9366-9372 (2010).   DOI   ScienceOn
23 Choi, L., Han, Y.N., Lee, K.T., Park, K.Y., Kwak, T.S., Kwon, S.H. and Park, H.L.: Anti-lipid peroxidative principles from the stem bark of Kalopanax pictus Nakai. Arch. Pharm. Res., 24, 536-540 (2001).   DOI   ScienceOn
24 Choi, J., Huh, K., Kim, S.H., Lee, K.T., Park, H.J. and Han, Y.N.: Antinociceptive andanti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. J. Ethnopharmacol., 79, 199-204 (2002).   DOI   ScienceOn