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Assessment of Pubertal Development to Parabens-induced Estrogenic Effect in Male Mice  

Kim, Sun-Jung (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Hwang, Jae-Woong (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Park, Jung-Ran (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Lee, Seong-Hun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Lee, Yeong-Geon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Chung, Ji-Hye (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Jeong, Yun-Hyeok (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Lee, Soo-Jin (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Jung, Ji-Won (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Jung, Ji-Youn (Department of Companion and Laboratory Animal Science, Kongju National University)
Lee, Yong-Soon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Kang, Kyung-Sun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Food Hygiene and Safety / v.21, no.4, 2006 , pp. 197-203 More about this Journal
Abstract
Parabens are most wildly used in food, cosmetics and pharmaceutic products as preservatives caused of safety and cheap. we had examined that paraben had estrogenic activity through the in vivo and in vitro experiments in last year. We demonstrated that most of parabens(ethyl, butyl, propyl, isobutyl, isopropyl) increased significantly uterus weight as well as induced proliferation of MCF-7 cell and binding of estrogen receptor as endocrine disrupter compounds. In this study, we evaluated that whether parabens have effect on male reproductive system or not. the male rats were administrated parabens by oral injection then examined separation of preputial day for $PND23\simPND52$. As the results, most parabens delayed pubertal development compare to control group. The separation of preputial day of Butyl and Propyl parabens at high concentration were PND 44 days and PND 45days compared to control group as PND 40 days. Even though, parabens as endocrine disrupter wildly spread in food, cosmetics and pharmaceutic products, we didn't have the safe guideline. In abroad, they are re-evaluating safety assessment for parabens. In conclusion, parabens delayed pubertal development in juvenile parabens are consider as endocrine disrupter chemicals.
Keywords
parabens; estrogenic activity; endocrine disrupter; preputial day;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Gomez, E., Pillon, A., Fenet, H., Rosain, D., Duchesne, M.J., Nicolas, J.C., Balaguer, P., and Casellas, C.: Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks
2 Oishi, S., Lack of spermatotoxic effects of methyl and ethyl esters of p-hydroxybenzoic acid in rats. Food Chem Toxicol. 42, 1845-1849 (2004)   DOI   ScienceOn
3 Oishi, S., Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 40, 1807-1813 (2002)   DOI   ScienceOn
4 Kang, K.S., Che, J.H., Ryu, D.Y, Kim, T.W., Li, G.X., and Lee, Y/S.: Decreased sperm number and motile activity on the Fl offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben). J Vet Med Sci. 64, 227-235 (2002)   DOI   ScienceOn
5 Jo, E.H., Jung, J.Y., Park, C.B., Park, S.H., Lee, Y.S., and Kang, K.S.: Estrogenic activity of parabens in yterotrophic assay. J of food hygiene and safety. 21, 118-128 (2006)   과학기술학회마을
6 Oishi, S., Effects of butyl paraben on the male reproductive system in mice. Arch Toxicol. 76, 423-429 (2002)   DOI
7 Bjerregaard, P., Andersen, D.N., Pedersen, K.L., Pedersen, S.N., and Korsgaard, B.: Estrogenic effect of propylparaben (propylhydroxybenzoate) in rainbow trout Oncorhynchus mykiss after exposure via food and water. Comp Biochem Physiol C Toxicol Pharmacol. 136, 309-317 (2003)   DOI   ScienceOn
8 Darbre, P.D.: Underarm cosmetics and breast cancer. Eur J Cancer. 13, 153 (2004)   DOI
9 Darbre, P.D., Aljarrah, A., Miller, W.R., Coldham, N.G, Sauer, M.J. and Pope, GS.: Concentrations of parabens in human breast tumours. J Appl Toxicol. 24, 5-13 (2004)   DOI   ScienceOn
10 Soni, M.G., Carabin, I.G. and Burdock, G.A.: Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol., 43, 985-1015 (2005)   DOI   ScienceOn
11 Lee, S.H., Kim, S.J., Park, J.R., Lee, Y.S., and Kang, K.S.: Estrogenic activity of parabens in vitro Estrogen Assay. J of food hygiene and safety. 21, 100-106 (2006)   과학기술학회마을