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http://dx.doi.org/10.9721/KJFST.2022.54.1.66

Properties of β-carotene-loaded chitosan/hyaluronic acid nanocapsules: solubility and redispersibility  

An, Eun Jung (Department of Food and Nutrition, Hanyang University)
Lee, Ji-Soo (Department of Food and Nutrition, Hanyang University)
Lee, Hyeon Gyu (Department of Food and Nutrition, Hanyang University)
Publication Information
Korean Journal of Food Science and Technology / v.54, no.1, 2022 , pp. 66-74 More about this Journal
Abstract
To improve the solubility of β-carotene, three types of β-carotene-loaded nanocapsules were prepared using chitosan (CS) and two cross-linkers, sodium tripolyphosphate (TPP) and hyaluronic acid (HA), alone or in combination (CS-TPP, CS-TPP-HA, and CS-HA). The entrapment efficiency of all nanocapsules significantly increased with an increase in TPP and HA, with the efficiency ranging from 95% to 99%. The solubility of β-carotene was significantly improved by CS nanoencapsulation before and after lyophilization and during storage. CS/HA nanoencapsulation significantly improved (by 11-fold) the water solubility of β-carotene. In particular, CS/HA nanoencapsulation was the most effective in terms of not only the solubility of β-carotene, but also the redispersibility ratio. Therefore, CS/HA encapsulation could be useful for improving the solubility of poorly soluble active ingredients, such as β-carotene.
Keywords
${\beta}$-carotene; solubility; nanoencapsulation; hyaluronic acid; redispersibility;
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