Anti-diabetic effects of common buckwheat and tartary buckwheat in type II diabetes animal model
![]() |
Kim, Su Jeong
(Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration)
Sohn, Hwang Bae (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration) Choi, Ji Myung (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University) Cho, Eun Ju (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University) Nam, Jung Hwan (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration) Lee, Jong Nam (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration) Suh, Jong Taek (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration) Chang, Dong Chil (Bioenergy Crop Research Institute, National Institute of Crop Science, Rural Development Administration) Kim, Yul Ho (Central Area Crop Breeding Division, National Institute of Crop Science, Rural Development Administration) |
1 | Dewanto V, Xianzhong W, Liu RH. Processed sweet corn has higher antioxidant activity. J. Agr. Food Chem. 50: 4959-4964 (2002) DOI |
2 | Folin O, Denis W. On phosphotungstic phosphomolybdic compounds as color reagents. J. Biol. Chem. 12: 239-249 (1912) DOI |
3 | Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed. Pharmacother. 96: 305-312 (2017) DOI |
4 | Lee DG, Jang IS, Yang KE, Yoon SJ, Baek SJ, Lee JY, Suzuki T, Chung KY, Woo SH, Choi JS. Lee HH. A study on the utilization of functional cosmetics materials using the bioactive compounds from buckwheat. Kor. J. Aesthet. Cosmetol. 6: 1-8 (2008) |
5 | Gordon T, Castelli WP, Hjortland M, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62: 707-714 (1977) DOI |
6 | Choi Y, Lee SM, Chun J, Lee HB, Lee J. Influence of heat treatment on the antioxidant activities and polyphenolic compounds of shiitake (Lentinus edodes) mushroom. Food Chem. 99: 381-387 (2006) DOI |
7 | Faerch K, Borch-Johnsen K, Holst JJ, Vaag A. Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes? Diabetol. 52: 1714-1723 (2009) DOI |
8 | Fernandes AA, Novelli EL, Okoshi K, Okoshi MP, Di Muzio BP, Guimaraes JF, Fernandes Junior A. Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomed Pharmacother 64: 214-219 (2010) DOI |
9 | Hue JJ, Kim JS, Kim JH, Nam SY, Yun YW, Jeong JH, and Lee BJ. Antiglycemic effect of carnosine in diabetic mice J. Fd. Hyg. Safety 24: 391-397 (2009) |
10 | Hwang JY, Han JS. Inhibitory effects of Sasa borealis leaves extracts on carbohydrate digestive enzymes and postprandial hyperglycemia. J. Korean Soc. Food Sci. Nutr. 36: 989-994 (2007) DOI |
11 | Jeon YH, Moon JW, Kweon HJ, Jeoung YJ, An CS, Jin HL, Hur SJ, Lim BO. Effects of Lycii fructus and Astragalus membranaceus mixed extracts on immunomodulators and prevention of diabetic cataract and retinopathy in streptozotocin-induced diabetes rat model. Korean J. Medicinal Crop Sci. 18: 15-21 (2010) |
12 | Kreft M. Buckwheat phenolic metabolites in health and disease. Nutr. Res. Rev. 29: 30-39 (2016) DOI |
13 | Kappel VD, Cazarolli LH, Pereira DF, Postal BG, Zamoner A, Reginatto FH, Silva FRMB. Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle. J. Pharm. Pharmacol. 65: 1179-1186 (2013) DOI |
14 | Kim SH, Hwang SY, Park OS, Kim MK, Chung YJ. Effect of Pinus densiflora extract on Blood glucose level, OGTT and biochemical parameters in streptozotocin induced diabetic rats. J Korean Soc. Food Sci. Nutr. 4: 973-979 (2005) |
15 | Kim HB, Kim SL. Quantification and varietal variation of rutin in mulberry fruits. Korean J. Seric. Sci. 46: 1-5 (2004) |
16 | Kim SJ, Kim YH. Agricultural guide Buckwheat. Rural Development Administration, Jeonju, Korea. pp. 7-90 (2018) |
17 | Kim JH, Pan JH, Cho HT, Kim YJ. Black ginseng extract counteracts streptozotocin-induced diabetes in mice. PLoS One 11, doi:10.1371 (2016) DOI |
18 | Kwon HW, Koo GB, Lee YJ, Kim JH, Lee MH, In G. Effect of Korean red ginseng extract (KGC05P0) on regulating insulin sensitivity, insulin and blood glucose level in hyperinsulinemia type 2 diabetic mice. J. Korean Soc. Food Sci. Nutr. 49: 539-546 (2020) DOI |
19 | Son HK, Lee YM, Park YH, Lee JJ. Effect of young barley leaf powder on glucose control in the diabetic rats. Korean J. Community Living Sci. 27: 19-29 (2016) DOI |
20 | Yoon BR, Cho BJ, Lee HK, Kim DJ, Rhee SK, Hong HD, Kim KT, Cho CW, Choi HS, Lee BY, Lee OH. Antioxidant and anti-adipogenic effects of ethanolic extracts from tartary and common buckwheats. Korean J. Food Preserv. 19: 123-130 (2012) DOI |
21 | Khaki A, Fathiazad F, Ahmadi-Ashtiani HR, Rezazadeh SH, Rastegar H, Imani AM. Compartments of quercetin & allium cepa (onion) on blood glucose in diabetic rats. J Med Plants (Suppl 6) 9: 107-12 (2010) |
22 | Hosseini A, Shafiee-Nick R, Ghorbani A. Pancreatic beta cell protection/regeneration with phytotherapy. Braz. J. Pharm. Sci. 51: 1-16 (2015) DOI |
23 | Hwang EJ, Lee SY, Kwon SJ, Park MH, Boo HO. Antioxidative, antimicrobial and cytotoxic activities of Fagopyrum esculentum Moench extract in germinated seeds. J. Korean Medicinal Crop Sci. 4: 1-7 (2006) |
24 | Kamalakkannan N, Prince PSM. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues, Mol. Cell. Biochem. 293: 211-219 (2006) DOI |
25 | Park CH, Kim YB, Choi YS, Heo K, Kim SL, Lee KC, Chang KJ, Lee HB. Rutin content in food products processed from groats, leaves, and flowers of buckwheat. Fagopyrum 17: 63-66 (2000) |
26 | Kim HA. Isolation and characterization of antidiabetic compounds from buckwheat, Department of food science and technology Graduate School, Kunsan National University. Kunsan, Korea (2006) |
27 | Lee JS, Park SJ, Sung KS, Han CK, Lee MH, Jung CW, Kwon TB. Effects of germinated-buckwheat on blood pressure, plasma glucose and lipid levels of spontaneously hypertensive rats. Korean J. Food Sci. Technol. 32: 206-211 (2000) |
28 | Lee MY, Shin IS, Jeon WY, Shin N, Shin HK. Bangpungtongseongsan, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge. Int. J. Mol. Med. 33: 978-986 (2014) DOI |
29 | Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. Ind. J. Exp. Biol. 52: 720-727 (2014) |
30 | Park SM. Strategies for development of anti-diabetic functional foods. Food Sci. Ind. 40: 46-58 (2007) DOI |
31 | Park JE, Lee GH, Kim JH, Choi SW, Kim EJ. Anti-obesity effect of Ramulus mori extracts and stilbenes in high fat diet-fed C57BL/6J mouse. J. Nutr. Health 53: 570-582 (2020) DOI |
32 | Suk JH, Kim MK, Ju JW, Han JS, Park JH. The effect of green tea polyphenol on plasma glucose, lipid levels and antioxidant system in type 2 diabetes patients. J. Korean Diabetes Assoc. 30: 217-225 (2006) DOI |
33 | Kim SL, Kim SK, Park CH. Introduction and nutritional evaluation of buckwheat sprouts as a new vegetable. Food Res. Int. 37: 319-327 (2004) DOI |
34 | Kim SJ, HB Sohn, Hong SY, Lee JN, Kim KD, Suh JT, Nam JH, Chang DC, Park MW, Kim YH. Construction of data system on seed morphological traits and functional component in tartary buckwheat germplasm. Korean J. Plant Res. 33: 446-459 (2020) DOI |
35 | Rhee SY, Woo TJ, Chon S, Hwang YC, Oh S, Ahn KJ, Chung HY, Kim SW, Kim JW, Kim YS. Characteristics of insulin resistance and insulin secretory capacity in Korean subjects with IFG and IGT. Diabetes Res. Clin. Pract. 89: 250-255 (2010) DOI |
36 | Sakihama Y, Cohen MF, Grace SC, Yamasaki H. Plant phenolic antioxidant and pro-oxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicol. 177: 67-80 (2002) DOI |
37 | Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am. J. Clin. Nutr. 81: 215S-217S (2005) DOI |
38 | Vinayagam R, Jayachandran M, Xu B. Antidiabetic effects of simple phenolic acids: A comprehensive review. Phytother. Res. 30: 184-199 (2016) DOI |
39 | Kim SJ, Sohn HB, Lee KT, Shin JS, Kim SY, Nam JH, Hong SY, Suh JT, Chang DC, Kim YH. Anti-inflammatory effects of seed ethanolic extracts of the common buckwheat and tartary buckwheat are mediated through the suppression of inducible nitric oxide synthase and pro-inflammatory cytokines. in LPS-induced RAW 264.7 macrophage cells. Korean J. Food Sci. Technol. 51: 565-575 (2019) DOI |
40 | Kim SJ, Sohn HB, Kim GH, Lee YY, Hong SY, Kim KD, Nam JH, Chang DC, Suh JT, Koo BJ, Kim YH. Comparison and validation of rutin and quercetin contents according to the extraction method of tartary Buckwheat (Fagopyrum tataricum Gaertn.) Korean J. Food Sci. Technol. 49: 258-264 (2017) DOI |
41 | Kreft S, Janes D, Kreft I. The content of fagopyrin and polyphenols in common and tartary buckwheat sprouts. Acta Pharm. 63: 553-560 (2013) DOI |
42 | Kreft I, Zhou M, Golob A, Germ M, Likar M, Dziedzic K, Luthar Z. Breeding buckwheat for nutritional quality. Breed. Sci. 70: 67-73 (2020) DOI |
43 | Khan A, Pessin J. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetol. 45: 1475-1483 (2002) DOI |
44 | Lee KH, Ham HM, Kim HJ. Park HY, Sim EY, Oh SK, Kim WH, Jeong HS, Woo KS. Functional components and radical scavenging activity of germinated brown rice according to variety. Korean J. Food Nutr. 29: 145-152 (2016) DOI |
45 | Son HK, Han JH, Lee JJ. Anti-diabetic effect of the mixture of mulberry leaf and green tea powder in rats with streptozotocininduced diabetes. Korean J. Food Preserv. 21: 549-559 (2014) DOI |
46 | Janbaz KH, Saeed SA, Gilani AH. Protective effect of rutin on paracetamol-and CCl 4-induced hepatotoxicity in rodents. Fitoterapia 73: 557-563 (2002) DOI |
47 | Wu WL, Wang J, Qiu J, Li Z. The analysis of fagopyritols from tartary buckwheat and their anti-diabetic effects in KK-Ay type 2 diabetic mice and HepG2 cells. J. Functional Foods 50: 137-146 (2018) DOI |
48 | Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr. Metab. 23: 12-60 (2015) |
49 | Wilcox G. Insulin and insulin resistance. Clin Biochem. Rev. 26(2): 19-39 (2005) |
50 | Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic. Biol. Med. 10: 339-352 (1991) DOI |
51 | Matkovics B, Kotorman M, Varga C. Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol. Hung. 85: 29-38 (1998) |
52 | Lee EJ, Choi H, Yoon WC, Kim YS, Song BN, Lee MY, Park BR, Lee SH, Choi JH, Park SY. Anti-diabetic and Lipid Profile Effect of Astragalus membranaceus (Fisch.) bunge fermented by Aspergillus awamori in db/db mice. Korean J. Medicinal Crop Sci. 29: 263-272 (2021) DOI |
53 | Lee JS, Lee MH, Chang YK, Ju JS, Son HS. Effects of buckwheat diet on serum glucose and lipid metabolism in NIDDM. Korean J. Nutr. 28: 809-817 (1995) |
54 | Lee SZ, Park SH, Lee HS. Change in vivo lipid peroxidation and antioxidant defense system in streptozotocin-induced diabetic rats: a time course study. Korean J. Nutr. 34: 253-264 (2001) |
55 | Cai EP, Lin JK. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic β cells, J. Agric. Food Chem. 57: 9817-9827 (2009) DOI |
56 | Yang J, Guo J, Yuan J. In vitro antioxidant properties of rutin. LWTFood Sci. Technol. 41(6): 1060-1066 (2008) |
57 | Adeghate E, Parvez SH. Nitric oxide and neuronal and pancreatic beta cell death. Toxicol. 153: 143-156 (2000) DOI |
58 | Ahmed OM, Moneim AA, Yazid LA, Mahmoud AM. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetol. Croat. 39: 15-35 (2010) |
59 | Akondi RB, Kumar P, Annapurna A, Pujari M. Protective effect of rutin and naringin on sperm quality in streptozotocin (STZ) induced type 1 diabetic rats. Iran. J. Pharm. Res. 10: 585 (2011) |
60 | Alinejad B, Ghorbani A, Sadeghnia HR. Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death. Avicenna J. Phytomed. 3: 321 (2013) |
61 | Park HB, Jeong NH, Park IC. Studies on the purification and production of the D-pinitol and D-chiro-inositol from soybean and buckwheat. Ministry of Agriculture. pp. 2-77 (2004) |
62 | Redondo MJ, Fain PR, Eisenbarth GS. Genetics of type 1A diabetes. Recent Prog. Horm. Res. 56: 69-89 (2001) DOI |
63 | Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab. Rev. 30: 325-243 (1998) |
64 | Campbell CG. Buckwheat Fagopyrum esculentum Moench. Plant Genet. Resour., CAB International. pp. 3-93 (1997) |
![]() |