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http://dx.doi.org/10.9721/KJFST.2021.53.6.706

Suppression of reactive oxygen species generation as a part of antioxidative effect of plant extracts  

Song, Seon Beom (Department of Life Science, University of Seoul)
Chung, Gu June (Department of Life Science, University of Seoul)
Jung, Hee Jin (College of Pharmacy, Pusan National University)
Jang, Jung Yoon (College of Pharmacy, Pusan National University)
Chung, Hae Young (College of Pharmacy, Pusan National University)
Kim, Nam Deuk (College of Pharmacy, Pusan National University)
Lee, Ji-Hyeon (Department of Biological Sciences, Inha University)
Min, Kyungjin (Department of Biological Sciences, Inha University)
Park, Sun Yeong (Dain Natural Co., Ltd.)
Kwak, Chung Shil (Institute on Aging, Seoul National University College of Medicine)
Hwang, Eun Seong (Department of Life Science, University of Seoul)
Publication Information
Korean Journal of Food Science and Technology / v.53, no.6, 2021 , pp. 706-714 More about this Journal
Abstract
Chemical scavenging of reactive oxygen species (ROS) is considered a major mechanism of antioxidant effects, but preventing ROS generation can be more efficient in attenuating oxidative damage. In this study, the extracts of plants, Solanum lycopersicum, Ailanthus altissima, Equisetum arvense, and Oenothera biennis, were tested to determine whether their antioxidative effects are driven by the prevention of superoxide generation from mitochondria, a major ROS generator. While all the extracts efficiently attenuated the elevation of ROS levels in human fibroblasts and inflammation-induced mice, those of S. lycopersicum, A. altissima, and O. laciniata only suppressed mitochondrial ROS generation and reduced levels of lipofuscin and lipid peroxidation. Furthermore, the extracts of A. altissima and O. laciniata extended the lifespan of fruit flies. Our results suggest that plant extracts with anti-oxidative effects differ in their ability to prevent ROS generation, which may be associated with the attenuation of oxidative damage in cells and animal tissues.
Keywords
Solanum lycopersicum; Ailanthus altissima; Equisetum arvense; Oenothera biennis; antioxidative effect; mitochondria ROS; lipofuscin;
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