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http://dx.doi.org/10.9721/KJFST.2021.53.5.544

Effect of Paeoniae Radix Alba on a thioacetamide induced liver fibrosis mice model  

Lee, Se Hui (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Lee, Jin A (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Shin, Mi-Rae (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Seo, Bu-Il (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Roh, Seong-Soo (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Publication Information
Korean Journal of Food Science and Technology / v.53, no.5, 2021 , pp. 544-552 More about this Journal
Abstract
This study investigated the anti-fibrotic and antioxidant effects of Paeonia Radix Alba water extract (PR) on thioacetamide (TAA)-induced liver fibrosis in a mouse model and its underlying mechanisms. Liver fibrosis was induced by intraperitoneal injection of TAA (three times a week) for 8 weeks. Furthermore, silymarin (50 mg/kg body weight) and PR (200 mg/kg body weight) were administered for 8 weeks. PR treatment downregulated aspartate aminotransferase (AST), alanine aminotransferase (ALT), ammonia, and myeloperoxidase levels. Moreover, PR treatment downregulated NOX2 and p47phox and upregulated antioxidant enzymes by activating the Nrf2/Keap1 signaling pathway. Furthermore, PR inhibited the factors associated with fibrosis, such as α-SMA and collagen I. AMPK/SIRT1 was upregulated by PR treatment. Overall, these results suggest that PR attenuates liver fibrosis by regulating the Nrf2/Keap1 and AMPK/SIRT1/NF-κB signaling pathways through the inhibition of oxidative stress. Hence, PR has potential as a remedy for preventing and treating liver fibrosis.
Keywords
liver fibrosis; Paeoniae Radix Alba; oxidative stress; antioxidant; thioacetamide;
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Times Cited By KSCI : 2  (Citation Analysis)
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