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http://dx.doi.org/10.9721/KJFST.2021.53.3.260

Hepatoprotective effect of fermented Chrysanthemum indicum L. water extract on ethanol-induced liver injury in HepG2 cells  

Seo, Tae-Su (R&D Center, Sungyibio)
Han, Joon-Hee (Department of Research and Development, Chuncheon Bioindustry Foundation)
Hong, Min (Department of Research and Development, Chuncheon Bioindustry Foundation)
Choi, Da-Hye (Department of Research and Development, Chuncheon Bioindustry Foundation)
Lee, Deug-Chan (Department of Medical Biotechnology School of Biomedical Science Kangwon National University)
Yu, Keun-Hyung (Food&Drug Business Headquarters, Adbiotech)
Publication Information
Korean Journal of Food Science and Technology / v.53, no.3, 2021 , pp. 260-266 More about this Journal
Abstract
This study aimed to identify the hepatoprotective effects of a fermented Chrysanthemum indicum L. water extract. The extraction yield, antioxidant activities (ABTS and DPPH), and content of luteolin and luteolin-7-glucoside were significantly higher in the fermented C. indicum L. water extract (FCI) than in the C. indicum L. water extract. Treatment with FCI (200 ㎍/mL) significantly reduced the activities of gamma(γ)-glutamyl transferase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase in HepG2 cells treated with 3% ethanol. Furthermore, FCI did not affect the viability of the HepG2 cells. These results suggest that FCI can be useful for the development of an effective hepatoprotective agent.
Keywords
Chrysanthemum indicum L.; fermentation; luteolin; antioxidant; hepatoprotective;
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Times Cited By KSCI : 3  (Citation Analysis)
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