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http://dx.doi.org/10.9721/KJFST.2019.51.5.466

Beneficial effect of collagen hydrolysate containing collagen tripeptides on ultraviolet B-induced skin photoaging  

Kim, Ae-Hyang (Amicogen Inc. Biotech R&D Center)
Ha, Min Woo (Amicogen Inc. Biotech R&D Center)
Kim, Jun Il (Amicogen Inc. Biotech R&D Center)
Piao, Zhe (Amicogen Inc. Biotech R&D Center)
Shin, Yong Chul (Amicogen Inc. Biotech R&D Center)
Shin, Daekeun (Amicogen Inc. Biotech R&D Center)
Publication Information
Korean Journal of Food Science and Technology / v.51, no.5, 2019 , pp. 466-472 More about this Journal
Abstract
This study was conducted to investigate anti-photoaging effects of collagen hydrolysate containing collagen tripeptides (CTP) in both HaCaT cells and SKH-1 hairless mice. CTP treatment was nontoxic to HaCaT cells and improved expression of biomarkers associated with aging of skin, such as, collagen 1A, metalloproteinase (MMP)-1, and MMP-13 after subjecting mice to ultraviolet B (UVB) irradiation. In animal studies, the depth and width of wrinkles in the skin of mice were determined upon subjecting them to UVB irradiation. However, positive effects on wrinkles on the skin of mice were seen following CTP supplementation. Collagen content and density of mouse skin were restored following CTP supplementation for 14 weeks after UVB irradiation. These results were based on the effects of CTP on protein levels of collagen 1A, MMP-1, and MMP-13. Therefore, CTP might have positive effects on the number, depth, and width of wrinkles caused by UVB irradiation in SKH-1 hairless mice.
Keywords
collagen tripeptides; collagen hydrolysate; anti-photoaging; ultraviolet B; skin wrinkle;
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Times Cited By KSCI : 5  (Citation Analysis)
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1 Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H. Protective effect of pomegranate derived products on UVB-mediated damage in human reconstituted skin. Exp. Dermatol. 18: 553-561 (2009)   DOI
2 Borumand M, Sibilla S. Daily consumption of the collagen supplement pure gold collagen reduces visible signs of aging. Clin. Interv. Aging. 9: 1747-1758 (2014)   DOI
3 Chai HJ, Li JH, Huang HN, Li TL, Chan YL, Shiau CY, Wu CJ. Effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency. J. Biomed. Biotechnol. Article ID 757301 (2010)
4 Cho JM, Lee YH, Baek R-M, Lee SW. Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J. Plast. Reconstr. Aes. 64: e31-e39 (2011)   DOI
5 Dhital B, Durlik P, Rathod P, Gul-E-Noor F, Wang Z, Sun C, Chang EJ, Itin B, Boutis GS. Ultraviolet radiation reduces desmosine cross-links in elastin. Biochem. Biophys. Rep. 10: 172-177 (2017)
6 Jeon HY, Kim JK, Seo DB, Lee SJ. Effects of chlorophyll a on UVB-induced cellular responses and type I pN collagen synthesis in vitro. Korean J. Food Sci. Technol. 41: 700-705 (2009)
7 Jung K, Seifert M, Herrling TH, Fuchs J. UV-generated free radicals (FR) in skin: Their prevention by sunscreens and their induction by self-tanning agents. Spectrochim. Acta. A. 69: 1423-1428 (2008)   DOI
8 Khan BA, Akhtar N, Rasul A, Khan H, Murtaza G, Ali A, Khan KA, Zaman S, Jameel A, Waseem K, Mahmood T. Human skin, aging and antioxidants. J. Med Plants Res. 6: 1-6 (2012)   DOI
9 Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral intake of lowmolecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients. 10: 826 (2018a)   DOI
10 Kim AH, Kim YS, Piao Z, Shin YC, Ha MW. Cutaneous hydration effect of collagen hydrolysate containing collagen tripeptides. Korean J. Food Sci. Technol. 50: 420-429 (2018b)   DOI
11 Lee JY. Lee SY. Inhibitory efficacy of Smilaxchina L. on pro-collagen type-1 activity and MMP-1 gene expression in fibroblasts (CCD-986sk). J. Life Sci. 23: 1239-245 (2013)   DOI
12 Kim JK, Lee JH, Yang MS, Seo DB, Lee SJ. Beneficial effect of collagen peptide supplement on anti-aging against photodamage. Korean J. Food Sci. Technol. 41: 441-445 (2009)
13 Kim MS, Oh GH, Kim MJ, Hwang JK. Fucosterol inhibits matrix metalloproteinase expression and promotes type-1 procollagen production in UVB-induced HaCaT cells. Photochem. Photobiol. 89: 911-918 (2013)   DOI
14 Korac RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn. Rev. 5: 164-173 (2011)   DOI
15 Lee JH, Seo JH, Park YH, Kim WG, Lim KM, Lee SJ. The Effect of Hydroxyproline and Pro-Hyp Dipeptide on UV-damaged Skin of Hairless Mice. Korean J. Food Sci. Technol. 40: 436-442 (2008)
16 Lee MH, Kim HJ, Jung HA, Lee YK. Stimulation of the extracellular matrix production in dermal fibroblast by Areca catechu extract. J. Korea Acad. Industr. Coop. Soc. 14: 1857-1862 (2013)   DOI
17 Matts PJ. Solar ultraviolet radiation: definitions and terminology. Dermatol. Clin. 24: 1-8 (2006)   DOI
18 Misato Y, Yukihiko I, Masayoshi Y, Spyros G, Sachiyuki T, Masa-aki N, Shigeo O, Kohji Y. Oral Ingestion of collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. J. Agr. Food Chem. 65: 2315-2322 (2017)   DOI
19 Matsuda N, Koyama Y-I, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S, Takehana K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J. Nutr. Sci. Vitaminol. 52: 211-215 (2006)   DOI
20 Masaki H. Role of antioxidants in the skin: Anti-aging effects. J. Dermatol. Sci. 58: 85-90 (2010)   DOI
21 Mohamed MAA, Jung M, Lee SM, Lee TH, Kim J. Protective effect of Disporum sessile D. Don extract against UVB-induced photoaging via suppressing MMP-1 expression and collagen degradation in human skin cells. J. Photoch. Photobio. B. 133: 73-79 (2014)   DOI
22 Mukherjee PK, Maity N, Nema NK, Sarkar BK. Bioactive compounds from natural resources against skin aging. Phytomedicine. 19: 64-73 (2011)   DOI
23 Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagenderived peptides. Proc. Natl. Acad. Sci. 75: 871-875 (1978)   DOI
24 Pyun H-B, Kim M, Park J, Sakai Y, Numata N, Shin J-Y, Shin H-J, Kim D-U, Hwang J-K. Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Prev. Nutr. Food Sci. 17: 245-253 (2012)   DOI
25 Shin H-J, Park JI, Kwon C-J, Kim HY, Inoue N, Seiko K, Hwang JS. The effect of collagen peptide intake on UVB-induced skin damage in hairless mice. J. Korea Acad. Industr. Coop. Soc. 17: 611-621 (2016)
26 Zague V, de Freitas V, Da Costa Rosa M, de Castro GA, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J. Med. Food. 14: 618-624 (2011)   DOI
27 Sontakke SB, Jung J-H, Piao Z, Chung HJ. Orally available collagen tripeptide: Enzymatic stability, intestinal permeability and absorption of Gly-Pro-Hyp and Pro-Hyp. J. Agric. Food Chem. 64: 7127-7133 (2016)   DOI
28 Watson REB, Gibbs NK, Griffiths CEM, Sherratt MJ. Damage to skin extracellular matrix induced by UV exposure. Antioxid. Redox. Sign. 21: 1063-1077 (2014)   DOI
29 Yoon Y, Bae S, An S, Choe YB, Ahn KJ, An IS. Effects of ultraviolet radiation on the skin and skin cell signaling pathways. J. Korea Aesthet. Cosmetol. 11: 417-426 (2013)