Browse > Article
http://dx.doi.org/10.9721/KJFST.2019.51.1.81

Anti-obesity effect of 3,5-dicaffeoylquinic acid on high-fat diet mouse  

Kang, Jin Yong (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Seon Kyeong (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Kim, Jong Min (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Su Bin (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Yoo, Seul Ki (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Han, Hye Ju (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Kim, Dae Ok (Department of Food Science and Biotechnology, Kyung Hee University)
Heo, Ho Jin (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
Publication Information
Korean Journal of Food Science and Technology / v.51, no.1, 2019 , pp. 81-89 More about this Journal
Abstract
This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.
Keywords
3,5-dicaffeoylquinic acid; chlorogenic acid; obesity; p-AMPK; p-Akt;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Iqbal R, Anand S, Ounpuu S, Islam S, Zhang X, Rangarajan S, Chifamba J, Al-Hinai A, Keltai M, Yusuf S, INTERHEART study Investigators. Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation. 118: 1929-1937 (2008)   DOI
2 Jeon S. Regulation and function of AMPK in physiology and diseases. Exp. Mol. Med. 48: 1-13 (2016)
3 Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacognosy reviews. 4: 118-126 (2010)   DOI
4 Meng S, Cao J, Feng Q, Peng J, Hu Y. Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid.-based Compl. Alt. 2013: 1-11 (2013)
5 Mubarak A, Hodgson JM, Considine MJ, Croft KD, Matthews VB. Supplementation of a high-fat diet with chlorogenic acid is associated with insulin resistance and hepatic lipid accumulation in mice. J. Agric. Food Chem. 61: 4371-4378 (2013)   DOI
6 Ong KW, Hsu A, Tan BKH. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by AMPK activation. Biochem. Pharmacol. 85: 1341-1351 (2013)   DOI
7 Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T. Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. Diabetes. 52: 2905-2913 (2003)   DOI
8 Hung H, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, Colditz GA, Rosner B, Spiegelman D, Willett WC. Fruit and vegetable intake and risk of major chronic disease. J. Natl. Cancer I. 96: 1577-1584 (2004)   DOI
9 Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 120: 1183-1192 (2001)   DOI
10 Prasai MJ, Mughal RS, Wheatcroft SB, Kearney MT, Grant PJ, Scott EM. Diurnal variation in vascular and metabolic function in diet-Induced obesity: divergence of insulin resistance and loss of clock rhythm. Diabetes. 62: 1981-1989 (2013)   DOI
11 Stevens J, Oakkar EE, Cui Z, Cai J, Truesdale KP. US adults recommended for weight reduction by 1998 and 2013 obesity guidelines, NHANES 2007-2012. Obesity. 23: 527-531 (2015)   DOI
12 Takenaka M, Yan X, Ono H, Yoshida M, Nagata T, Nakanishi T. Caffeic acid derivatives in the roots of Yacon (Smallanthus sonchifolius). J. Agric. Food Chem. 51: 793-796 (2003)   DOI
13 Tong J, Ma B, Ge L, Mo Q, Zhou G, He J, Wang Y. Dicaffeoylquinic acid-enriched fraction of Cichorium glandulosum seeds attenuates experimental type 1 diabetes via multipathway protection. J. Agric. Food Chem. 63: 10791-10802 (2015)   DOI
14 Zhang H, Tong TK, Qiu W, Zhang X, Zhou S, Liu Y, He Y. Comparable effects of high-intensity interval training and prolonged continuous exercise training on abdominal visceral fat reduction in obese young women. J. Diabetes Res. 2017: 1-9 (2017)
15 Trombetta M, Spiazzi G, Zoppini G, Muggeo M. Type 2 diabetes and chronic liver disease in the verona diabetes study. Aliment. Pharmacol. Ther. 22: 24-27 (2005)   DOI
16 Wan C, Wong CN, Pin W, Wong MH, Kwok C, Chan RY, Yu PH, Chan S. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-${\alpha}$ in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother. Res. 27: 545-551 (2013)   DOI
17 Xu J, Hu Q, Liu Y. Antioxidant and DNA-protective activities of chlorogenic acid isomers. J. Agric. Food Chem. 60: 11625-11630 (2012)   DOI
18 Xu Y, Zhang M, Wu T, Dai S, Xu J, Zhou Z. The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet. Food Funct. 6: 296-303 (2015)   DOI
19 Yun JW. Possible anti-obesity therapeutics from naturea review. Phytochemistry. 71: 1625-1641 (2010)   DOI
20 Angulo P. Nonalcoholic fatty liver disease. New. Engl. J. Med. 346: 1221-1231 (2002)   DOI
21 Armstrong AJ, George DJ, Halabi S. Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. J. Clin. Oncol. 30: 3402-3407 (2012)   DOI
22 Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr. Opin. Lipidol. 19: 295-300 (2008)   DOI
23 Brasnyo P, Molnr GA, Mohs M, Mark L, Laczy B, Cseh J, Mikols E, Szijrt IA, Mrei A, Halmai R. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Brit. J. Nutr. 106: 383-389 (2011)   DOI
24 Carnat A, Heitz A, Fraisse D, Carnat A, Lamaison J. Major dicaffeoylquinic acids from Artemisia vulgaris. Fitoterapia. 71: 587-589 (2000)   DOI
25 Cho A, Jeon S, Kim M, Yeo J, Seo K, Choi M, Lee M. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem. Toxicol. 48: 937-943 (2010)   DOI
26 Farah A, Donangelo CM. Phenolic compounds in coffee. Brazilian J. Plant Physiol. 18: 23-36 (2006)   DOI
27 Hong S, Joo T, Jhoo J. Antioxidant and anti-inflammatory activities of 3,5-dicaffeoylquinic acid isolated from Ligularia fischeri leaves. Food Sci. Biotechnol. 24: 257-263 (2015)   DOI
28 Feng Y, Yu Y, Wang S, Ren J, Camer D, Hua Y, Zhang Q, Huang J, Xue D, Zhang X. Chlorogenic acid protects d-galactose-induced liver and kidney injury via antioxidation and anti-inflammation effects in mice. Pharm. Biol. 54: 1027-1034 (2016)   DOI
29 Folch J, Lees M, Sloane Stanley G. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509 (1957)   DOI
30 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502 (1972)   DOI
31 Hopps E, Noto D, Caimi G, Averna M. A novel component of the metabolic syndrome: The oxidative stress. Nutr. Metabol. Cardiovascular Dis. 20: 72-77 (2010)   DOI