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http://dx.doi.org/10.9721/KJFST.2019.51.1.52

Inhibitory effects of crude polysaccharide fractions from Annona muricata L. on melanogenesis  

Kim, Yi-Eun (Department of Food Science and Technology, Kongju National University)
Byun, Eui-Hong (Department of Food Science and Technology, Kongju National University)
Publication Information
Korean Journal of Food Science and Technology / v.51, no.1, 2019 , pp. 52-57 More about this Journal
Abstract
The objective of this study was to evaluate the anti-melanogenic effects of crude polysaccharide fractions from Annona muricata L. (ALP) in 3-isobutyl-1-methylxanthine (IBMX) stimulating hormone-induced mouse B16F10 melanoma cells. The inhibitory effect of ALP on tyrosinase activity was approximately $33.88{\pm}0.79%$ at 5 mg/mL. Additionally, the B16F10 cellular tyrosinase and melanin synthesis inhibition activities by ALP were $54.21{\pm}4.76$ and $56.74{\pm}6.97%$ at $250{\mu}g/mL$, respectively. Similarly, whitening-related protein tyrosinase, tyrosinase-related protein 1 (TRP-1) and TRP-2, and microphthalmia-associated transcription factor (MITF) were reduced by ALP treatment. These results indicated that ALP could be used as a functional cosmetic ingredient after confirming its whitening activity related to melanin content.
Keywords
Annona muricata L.; tyrosinase; melanin synthesis; whitening activity; microphthalmia-associated transcription factor (MITF);
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Times Cited By KSCI : 4  (Citation Analysis)
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