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http://dx.doi.org/10.9721/KJFST.2017.49.5.538

Neuroprotective effects of astringency-removed peel extracts of Diospyros kaki Thunb. cv. Cheongdo-Bansi on oxidatively-stressed PC-12 cells  

Jeong, Da-Wool (Department of Food Science and Biotechnology, Kyung Hee University)
Cho, Chi Heung (Department of Food Science and Biotechnology, Kyung Hee University)
Rha, Chan Su (Department of Food Science and Biotechnology, Kyung Hee University)
Lee, Seung Hwan (School of Food Science and Industry, Kyungil University)
Kim, Dae-Ok (Department of Food Science and Biotechnology, Kyung Hee University)
Publication Information
Korean Journal of Food Science and Technology / v.49, no.5, 2017 , pp. 538-543 More about this Journal
Abstract
Astringent persimmon (Diospyros kaki Thunb. cv. Cheongdo-Bansi) peel with the astringency removed, which is a by-product of dried persimmon (gotgam), was investigated for its antioxidant and neuroprotective properties. A mixture of peel and 40% (v/v) aqueous ethanol was subjected to ultrasonication and then thermal and nonthermal treatments, to produce thermally-treated and nonthermally-treated persimmon peel extracts (TPE and NTPE, respectively). The total phenolic and flavonoid contents and the antioxidant capacity of TPE was approximately 1.3-1.8 times higher than those of NTPE. TPE resulted in the increased viability of neuronal PC-12 cells compared with NTPE. Furthermore, intracellular oxidative stress in PC-12 cells was more decreased by treatment with TPE than NTPE. Cholinesterases, such as acetylcholinesterase and butyrylcholinesterase, were more inhibited by treatment with TPE than NTPE. These results suggest that TPE is useful as a functional material to decrease oxidative stress in neuronal cells and to inhibit cholinesterases.
Keywords
acetylcholinesterase; astringent persimmon; butyrylcholinesterase; removal of astringency; vitamin C equivalents;
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Times Cited By KSCI : 5  (Citation Analysis)
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