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http://dx.doi.org/10.9721/KJFST.2016.48.6.582

Synergistic effects of grape branch and Pleurotus eryngii extract combination against inflammation on activated mast cells and atopic dermatitis-like skin lesions in mice  

Yin, Hong Hua (Research Institute, Ato Q&A Corporation)
Cho, Byoung Ok (Research Institute, Ato Q&A Corporation)
Lee, Hye Seung (Department of Healthcare Management, Gwangju University)
Chu, Jung Im (Agri-Bio Institute, Jeonju University)
Jang, Seon Il (Research Institute, Ato Q&A Corporation)
Publication Information
Korean Journal of Food Science and Technology / v.48, no.6, 2016 , pp. 582-589 More about this Journal
Abstract
The aim of this study was to investigate the synergistic anti-inflammatory and anti-dermatitis effects of grape branch extract (GBE) and Pleurotus eryngii (PEE) combinations on the active immune cells and atopic dermatitis-like skin lesions in mice. The results showed that the combination of GBE ($12.5{\mu}g/mL$) and PEE ($500{\mu}g/mL$) led to much stronger inhibitory effects on the production of inflammatory mediators, such as NO and $PGE_2$ than that exhibited by GBE ($25{\mu}g/mL$) and PEE ($1000{\mu}g/mL$) alone, even at higher concentrations, in LPS-stimulated RAW 264.7 macrophages. The combination of GBE and PEE synergistically inhibited the production of TNF- and IL-6 in LPS-stimulated RAW 264.7 macrophages and PMA plus A23187-activated HMC-1 cells. Furthermore, combined GBE and PEE had a stronger ameliorative effect than GBE and PEE alone by inhibiting the clinical sores, IgE, and IL-4 on atopic dermatitis-like skin lesions in mice. Collectively, these results suggested that the combination of GBE and PEE produced a synergistic anti-inflammatory and anti-atopic dermatitis effect on immune cells and atopic dermatitis-like skin lesions in mice.
Keywords
grape branch; Pleurotus eryngii; anti-inflammation; anti-atopic dermatitis; synergistic effect;
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