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http://dx.doi.org/10.9721/KJFST.2013.45.5.628

Effects of Extracts of Unripe Black Raspberry and Red Ginseng on Cholesterol Synthesis  

Lee, Su Jung (Gochang Black Raspberry Research Institute)
Lee, Min Jung (Gochang Black Raspberry Research Institute)
Ko, Young Jong (Gochang Black Raspberry Research Institute)
Choi, Hye Ran (Gochang Black Raspberry Research Institute)
Jeong, Jong Tae (Gochang Black Raspberry Research Institute)
Choi, Kyung-Min (Institute of JinAn Red Ginseng)
Cha, Jeong-Dan (Institute of JinAn Red Ginseng)
Hwang, Seung-Mi (Institute of JinAn Red Ginseng)
Jung, Hoo Kil (Imsil Research Institute of Cheese Science)
Park, Jong Hyuk (Imsil Research Institute of Cheese Science)
Lee, Tae Bum (Gochang Black Raspberry Research Institute)
Publication Information
Korean Journal of Food Science and Technology / v.45, no.5, 2013 , pp. 628-635 More about this Journal
Abstract
We investigated the effects of water extracts of unripe black raspberry (UBR) and red ginseng (RG) on cholesterol synthesis, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity, and expression of low-density lipoprotein (LDL) or high-density lipoprotein (HDL)-related genes in HepG2 and Caco-2 (human hepatoma and intestinal cell lines, respectively). Our results showed that cholesterol synthesis and HMG-CoA reductase activity in HepG2 cells were inhibited by UBR and RG. Further, co-treatment with UBR and RG had a greater effect than did treatment with either UBR or RG. In Caco-2 cells, treatment with UBR and RG increased the expression of LDL-regulated genes, such as LDL receptor and SREBP-2, and also upregulated the level of HDL-associated ABCA1. Moreover, co-treatment with UBR and RG appeared to be more effective than treatment with either UBR or RG. Taken together, our results indicate that UBR and RG regulate the level of HDL-associated ABCA1 via signaling pathway, thereby preventing cholesterol synthesis.
Keywords
black raspberry; red ginseng; 3-hydroxy-3-methylglutaryl-CoA reductase; low-density lipoprotein; high-density lipoprotein;
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Times Cited By KSCI : 7  (Citation Analysis)
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