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http://dx.doi.org/10.9721/KJFST.2012.44.6.759

Phenethyl Isothiocyanate Inhibits Ovalbumin-induced Inducible Nitric Oxide Synthase Expression  

Shin, Hwa-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
Publication Information
Korean Journal of Food Science and Technology / v.44, no.6, 2012 , pp. 759-762 More about this Journal
Abstract
Egg allergies have been reported as one of the most prevalent food hypersensitivities in the pediatric population. One of the major egg allergens is ovalbumin (OVA), which is the major protein in the egg whites. Phenethyl isothiocyanate (PEIC) from cruciferous vegetables has an effect on anti-inflammatory therapy. In the present report, we show that PEIC inhibits the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation induced by OVA. PEIC also inhibits the OVA-induced inducible nitric oxide synthase (iNOS) expression and nitrite production. However, PEIC did not suppress the cyclooxygenase-2 (COX-2) expression induced by OVA. These results suggest that PEIC has the specific mechanism for anti-inflammatory responses and efficient anti-allergic activities.
Keywords
egg allergy; inducible nitric oxide synthase; NF-${\kappa}B$; ovalbumin; phenethyl isothiocyanate;
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