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http://dx.doi.org/10.9721/KJFST.2012.44.3.324

Effects of Lactobacillus plantarum CIB 001 on Lipid Metabolism of Hypercholesterolemic Rats  

Cha, Sang-Do (Biomaterials Research Center, Cellinbio)
Yu, Ji-Won (Biomaterials Research Center, Cellinbio)
Kim, Tae-Woon (R&D Division, World Institute of Kimchi)
Cho, Ho-Seong (College of Veterinary Medicine and Veterinary Diagnostic Center, Chonbuk National University)
Lee, Dong-Hee (Biomaterials Research Center, Cellinbio)
Publication Information
Korean Journal of Food Science and Technology / v.44, no.3, 2012 , pp. 324-330 More about this Journal
Abstract
The aim of the present study was to assess the anti-hypercholesterolemic effect of bile salt hydrolase-producing Lactobacillus plantarum CIB 001 (KCTC 11717 bp) in rats fed a high-cholesterol diet. Four treatment groups of rats (n=5) were fed experimental diets: a normal diet (ND), a ND plus L. plantarum CIB 001(NDL) at $5.0-7.5{\times}10^9$ colony forming unit (CFU)/day, a high-cholesterol diet (HCD), as well as a HCD plus L. plantarum CIB 001 (HCDL) at $5.0-7.5{\times}10^9$ CFU/day for 6 weeks. Compared with the HCD group, the HCDL group demonstrated a decrease in serum triglyceride (p<0.05), total cholesterol (p<0.05), and the corresponding HDL-cholesterol concentration increased at a rate of 40% (p<0.05). The HCDL group also induced a decrease in liver inflammation and steatosis. The present results suggest that supplementation of L. plantarum CIB 001 can have short-term (6 weeks) effects on blood lipids and liver injury, as well as on the atherogenic index and cardiac risk factors.
Keywords
Lactobacillus plantarum CIB 001; cholesterol-lowering; high-cholesterol diet; blood lipids;
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