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http://dx.doi.org/10.9721/KJFST.2012.44.2.251

Evaluation on Skin Irritation and Sensitization of Oxyresveratrol and Oxyresveratrol-3-O-glucoside Produced by Biotransformation of Morus alba Extract  

Park, Keun-Tae (Department of Biomedical Science, College of Health Science, Korea University)
Kim, Jeong-Keun (Department of Chemical Engineering and Biotechnology, Korea Polytechnic University)
Lim, Young-Hee (Department of Biomedical Science, College of Health Science, Korea University)
Publication Information
Korean Journal of Food Science and Technology / v.44, no.2, 2012 , pp. 251-256 More about this Journal
Abstract
Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of $Morus$ $alba$ root show skin irritation and sensitization. In skin irritation test, 1% oxyresveratrol (OXY), and 5% OXY, and 1% oxyresveratrol-3-$O$-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1% OXY, 5% OXY, and 1% OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0%. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.
Keywords
skin irritation; skin sensitization; Morus alba extract; guinea pig maximization test;
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