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http://dx.doi.org/10.9721/KJFST.2012.44.2.148

Monitoring of Forbidden Medicines as Adulterants in Dietary Supplements Marketed Online by HPLC and ESI-tandom Mass Spectrometry  

Lee, Yong-Cheol (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Kim, Bog-Soon (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Yun, Eun-Sun (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Kim, Sung-Dan (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Chang, Min-Su (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Park, Young-Ae (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Shin, Young (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Jung, Sun-Ok (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Lee, Jae-In (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Chae, Young-Zoo (Seoul Metropolitan Government Research Institute of Public Health and Environment)
Publication Information
Korean Journal of Food Science and Technology / v.44, no.2, 2012 , pp. 148-154 More about this Journal
Abstract
It was carried out to detect anti-impotence drug-like compounds, sibutramine and their analogues in dietary supplements, which are doubtful whether they include illegal compounds. A total of 51 food products were bought online and have been investigated. The separation was achieved on a C18 column, with the mobile phase made up of water (5 mM sodium hexanesulfonate and 0.1% phosphoric acid) and 95% acetonitrile, at a flow rate of 1.2 mL/min with gradient elution using by HPLC-DAD. The UV signals were monitored at 220 nm and 291 nm. LC-ESI-tandom MS was utilized to confirm that detected compounds in samples are the same as the reference materials. Two nutrient supplement foods and ginseng products were found to contain 1.3-82.1 mg of sildenafil, dimethylthiolsildenafil and pseudovardenafil per serving size. In addition, two other processed products were detected to contain 1.7 and 2.2 mg of didesmethylsibutramine, derived from sibutramine per serving size.
Keywords
anti-impotence drug; sildenafil; sibutramine; LC-ESI-MS;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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