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Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts  

Yang, Hee-Jin (Department of Food Science and Biotechnology, Sungkyunkwan University)
Park, Kye-Won (Department of Food Science and Biotechnology, Sungkyunkwan University)
Kim, Hyun-Suck (Sungkyun Biotech, Co., Ltd.)
Cho, Soo-Muk (Department of agro-Food Resources, National Academy of Agricultural Science)
Park, Ki-Moon (Department of Food Science and Biotechnology, Sungkyunkwan University)
Publication Information
Korean Journal of Food Science and Technology / v.42, no.1, 2010 , pp. 109-114 More about this Journal
Abstract
The in vivo and in vitro effects of oriental herb extracts of Cassia obtusifolia, Taraxacum platycarpum and Ulmusmacrocarpa on anti-atopic allergic reaction were evaluated in this study. A mixture of these extracts exhibited more potent anti-allergic activities in human mast cells than those from individual extracts. The herbal mixture significantly inhibited the release of compound 48/80-induced $\beta$-hexosaminidase release in the human mast cell line, HMC-1. The mixture also suppressed the production of PMA and A23187-induced inflammatory cytokines in HMC-1 cells. To further investigate the in vivo effects of the herbal mixture, a Dermatophagoides farinae (DF)-induced atopic dermatitis mouse model was utilized. Oral administration of the herbal mixture significantly decreased the ear thickness and swelling in DF treated NC/Nga mice in a dose dependent manner. Furthermore, serum levels of IgE and interleukin-4 (IL-4) were significantly decreased, whereas interferon-gamma (IFN-$\gamma$) levels were increased in the mixture administrated groups when compared to the control. Taken together, our data indicate the possibility of using a mixture of the oriental herb extract to relieve symptoms of atopic dermatitis.
Keywords
Cassia obtusifolia; Taraxacum platycarpum; Ulmus macrocarpa; anti-atopic allergic reaction;
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1 Jang HS. Diagnosis and treatment of atopic dermatitis. J. Korean Acad. Fam. Med. 23: 831-840 (2002)
2 Lee JH, Kim KH, Kim MN, Kim JW, Ro YS, Park YL. The treatment guideline of Korean atopic dermatitis. Ann. Dermatol.44: 907-913 (2006)
3 Dombrowicz D, Flamand V, Brigman KK, Koller BH, Kinet JP. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell 75: 969-976 (1993)   DOI   ScienceOn
4 Segawa S, Kuroda H, Kaneko T, Watari J. Oral administration of a hop water extract ameliorates the development of dermatitis induced by the periodical topical application of a mite antigen in atopic dermatitis model NC/Nga mice. Biosci. Biotech. Bioch. 72: 974-981 (2008)   DOI   ScienceOn
5 Park KM, Hwang JK, Shin KM, Kim HS, Song JH. Detoxicating effects of oriental herb extract mixtures on nicotine and dioxin. Korean J. Food Sci. Technol. 35: 980-987 (2003)
6 Hwang JK, Lee KJ, Yang HJ, Park KM. Protection and detoxification effects of oriental herb extract mixture on TCDD-Induced oxidative stress. J. Korean Soc. Food Nutr. 37: 294-301 (2008)   DOI
7 Matsubara M, Masaki S, Ohmori K, Karasawa A, Hasegawa K. Differential regulation of IL-4 expression and degranulation by antiallergic olopatadine in rat basophilic leukemi (RBL-2H3) cells. Biochem. Pharmacol. 35: 497-503 (2004)
8 Na HJ, Moon PD, Lee HJ, Kim HR, Chae HJ, Shin T, Seo Y, Hong SH, Kim HM. Regulatory effect of atopic allergic reaction by Carpopeltis affinis. J. Ethnopharmacol. 101: 43-48 (2005)   DOI
9 Kang JS, Yoon WK, Han MH, Lee H, Lee CW, Lee KH, Han SB, Lee K, Yang KH, Park SK, Kim HM. Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int. Immunopharmacol. 8: 1475-1480 (2008)   DOI   ScienceOn
10 Jeon JH, Kwon SC, Park D, Shin S, Jeong JH, Park SY, Hwang SY, Kim YB, Joo SS. Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction. Arch. Pharm. Res. 32: 823-830 (2009)   DOI
11 Scadding GK. Clinical assessment of antihistamines in rhinitis. Clin. Exp. Allergy 29: 77-81 (1999)
12 Trefzer U, Hofmann M, Sterry W, Asadullah K, Cytokine andanti-cytokine therapy in dermatology. Expert Opin. Biol. Th. 3: 733-743 (2003)   DOI   ScienceOn
13 Ahn KS, Kim SK, Moon KY, Hahn BS, Kang SS, Kim YS. Screening of crude drugs for the inhibitory effect on NF-$\kappa$B activation in transfectant HaCaT cells. Korean J. Pharmacogn. 34: 156-160 (2003)
14 Jiang J, Yamaguchi T, Funakushi N, Kuhara T, Fan PS, Ueki R, Suto H, Kase Y, Ikeda S, Ogawa H. Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J. Dermatol. Sci. 56: 37-42 (2009)   DOI   ScienceOn
15 Choi JH, Park CW, Lee CH. A study of histamine content in food in Korea. Korean J. Dermatol. 45: 768-771 (2007)
16 Taylor ML, Metcalfe DD. Mast cells in allergy and host defense. Allergy Asthma Proc. 22: 115-119 (2001)
17 Chun IK, Choi YS, Kim YP. Adverse effect of topical steroids. Ann. Dermatol. 20: 867-877 (1982)
18 Gomes JC, Di Stasi LC, Sgarbosa F, Barata LE. Pharmacological evaluation of the inhibitory effect of extracts from Anchieta salutaris on the histamine release induced in the rat and the guinea pig. Int. Arch. Allergy Imm. 103: 188-193 (1994)   DOI   ScienceOn
19 Church MK, Levi-Schaffer F. The human mast cell. J. Allergy Clin. Imm. 99: 155-160 (1997)   DOI   ScienceOn
20 Gao XK, Fuseda K, Shibata T, Tanaka H, Inagaki N, Nagai H. Kampo medicines for mite antigen-induced allergic dermatitis in NC/Nga mice. Evid-Based Compl. Alt. 2: 191-199 (2005)   DOI   ScienceOn
21 Metcalfe DD, Kaliner M, Donlon MA. The mast cell. Crit. Rev. Immunol. 3: 23-74 (1981)
22 Powrie F, Coffman RL. Cytokine regulation of T-cell function: Potential for therapeutic intervention. Immunol. Today 14: 270-27 (1993)   DOI   ScienceOn
23 Aioi A, Tonogaito H, Suto H, Hamada K, Ra CR, Ogawa H. Impairment of skin barrier function in NC/Nga Tnd mice as a possible model for atopic dermatitis. Br. J. Dermatol. 144: 12-18 (2001)   DOI   ScienceOn
24 Hamon M, Bourgoin S. Pharmacological profile of antidepressants: A likely basis for their efficacy and side effects? Eur. Neuropsychopharm. 549: 79-83 (2006)
25 Choi SP, Kang MY, Koh HJ, Nam SH, Friedman M. Antiallergic activities of pigmented rice bran extracts in cell assays. J. Food Sci. 72: S719-S726 (2007)   DOI
26 Kim EC, Lee HS, Kim SK, Choi MS, Lee S, Han JB, An HJ, Um JY, Kim HM, Lee NY, Bae H, Min BI. The bark of Betula platyphylla var. japonica inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. J. Ethnopharmacol. 116: 270-278 (2008)   DOI   ScienceOn
27 Na HJ, Moon PD, Ko SG, Lee HJ, Jung HA, Hong SH, Seo Y, Oh JM, Lee BH, Choi BW, Kim HM. Sargassum hemiphyllum inhibits atopic allergic reaction via the regulation of inflammatory mediators. J. Pharmacol. Sci. 97: 219-226 (2005)   DOI   ScienceOn
28 Rousset F, Robert J, Andary M, Bonnin JP, Souillet G, Chretien I, Briere F, Pene J, De Vries JE. Shifts in interleukin-4 and interferon-$\gamma$ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J. Allergy Clin. Immun. 87: 58-69 (1991)   DOI