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Anti-allergic Effect of Zizania latifolia Turcz Extracts  

Lee, Eun-Jung (Department of Food and Technology, Keimyung University)
Whang, Eun-Yeong (Department of Food and Technology, Keimyung University)
Whang, Key (Department of Food and Technology, Keimyung University)
Lee, In-Seon (Department of Food and Technology, Keimyung University)
Yang, Seun-Ah (The Center for Traditional Microorganism Resources, Keimyung University)
Publication Information
Korean Journal of Food Science and Technology / v.41, no.6, 2009 , pp. 717-721 More about this Journal
Abstract
The anti-allergic effect of the methanol extract of Zizania latifolia Turcz was investigated. Methanol extract of Z. latifolia Trucz did not display any cytotoxicity activities in the IgE-sensitized RBL-2H3 cells. The extract was found to inhibit compound 48/80-induced degranulation and antigen-induced $\beta$-hexosaminidase release as well as PMA plus A23187-induced TNF-$\alpha$ production in RBL-2H3 mast cells in a dose-dependent manner. Release of $\beta$-hexosaminidase, a marker for the release of histamine in mast cells, was inhibited with an $IC_{50}$ value of $73.8\;{\mu}g/mL$. These results suggest that Z. latifolia extracts may be useful for the prevention of type I allergic reaction.
Keywords
Zizania latifolia Turcz; $\beta$-hexosaminidase; degranulation; TNF-$\alpha$; RBL-2H3 cells;
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