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Anti-hypertensive Activities of Lactobacillus Isolated from Kimchi  

Yu, Mi-Hee (Department of Food Science and Technology, Keimyung University)
Im, Hyo-Gwon (Department of Food Science and Technology, Keimyung University)
Im, Nam-Kyung (Department of Food Science and Technology, Keimyung University)
Hwang, Eun-Young (Department of Food Science and Technology, Keimyung University)
Choi, Jun-Hyeok (Department of Food Science and Technology, Keimyung University)
Lee, Eun-Ju (Bio Research Institute, NUC Electronics Co. Ltd.)
Kim, Jong-Boo (Bio Research Institute, NUC Electronics Co. Ltd.)
Lee, In-Seon (Department of Food Science and Technology, Keimyung University)
Seo, Hwa-Jeong (Department of Food Science and Technology, Keimyung University)
Publication Information
Korean Journal of Food Science and Technology / v.41, no.4, 2009 , pp. 428-434 More about this Journal
Abstract
This study was conducted to evaluate the anti-hypertensive effect of Lactobacillus sp. isolated from Kimchi by examining its effects on renal angiotensin-converting enzyme (ACE) inhibitory activity, lipid components and blood pressure using the spontaneously hypertensive rat (SHR) system. Most Lactobacillus sp. extracts (lysozyme, sonication and ethyl acetate extracts) showed higher capacities for the inhibition of ACE activity than those of cultured media. Particularly, LG 7, 8 and 42 of Lactobacillus sp. showed the strongest inhibitory activity among the Lactobacillus sp. extracts. The concentrations of total cholesterol and triglycerides in the serum were lower in the Lactobacillus sp. administration groups than in the control group, but these differences were not significant. The HDL-cholesterol concentrations of the LG 42 administration groups (IX, X) were significantly higher than that of the control group. At 4 weeks, the systolic blood pressure (SBP) in the LG 42 Lactobacillus sp. ($1{\times}10^9$ cfu/mL) group (XI) was about 27% lower than that of the control group (V). No adverse effects were observed on the liver and there was no difference in the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values among groups. The results of this study suggest that long term consumption of LG 42 Lactobacillus sp. may be beneficial to the prevention of high blood pressure.
Keywords
Lactobacillus; Kimchi; ACE inhibitory activity; blood pressure; hypertension;
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Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 4
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