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Beneficial Effect of Curcumin on Epidermal Permeability Barrier Function in Hairless Rat  

Jeon, Hee-Young (Amorepacific Corporation R&D center)
Kim, Jeong-Kee (Amorepacific Corporation R&D center)
Kim, Wan-Gi (Amorepacific Corporation R&D center)
Lee, Sang-Jun (Amorepacific Corporation R&D center)
Publication Information
Korean Journal of Food Science and Technology / v.40, no.6, 2008 , pp. 686-690 More about this Journal
Abstract
Recent research has shown that curcumin has beneficial effects in a variety of skin diseases, including scleroderma, psoriasis, and skin cancer. In this study, we assessed the effects of curcumin on epidermal permeability barrier function in vivo and in vitro. In order to evaluate the effects of curcumin on epidermal permeability barrier function in vivo, hairless rats were exposed to UVB irradiation, and curcumin was administered orally at a dosage of 150 mg/kg per day for 8 weeks. Transepidermal water loss (TEWL) and epidermal thickness were measured at the end of the experiment. The expression of filaggrin, a marker of keratinocyte differentiation, and serine palmitoyltransferase (SPT), a marker of the formation of the stratum corneum lipid barrier, in human HaCat keratinocytes were analyzed. The in vivo results showed that an 8 week administration of curcumin markedly prevented the UVB-induced increase in TEWL. The UV-induced increase in epidermal thickness was also reduced significantly by curcumin treatment. The in vitro results demonstrated the concentration-dependent effects of curcumin on the expression of both filaggrin and SPT in HaCat cells, reflecting the notion that curcumin can induce epidermal keratinocyte differentiation and can improve the recovery of skin barrier functions. These results show that curcumin is a promising candidate for the improvement of epidermal permeability barrier function.
Keywords
curcumin; epidermal permeability barrier function; filaggrin; serine palmitoyltransferase;
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