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Antioxidant and Cell Proliferation Effects of Acanthopanax senticosus for Extract in Human Osteoblast-like MG-63 Cell Line  

Lim, So-Young (Department of Food and Nutrition, Yonsei University)
Leem, Jae-Yoon (College of Pharmacy, Woosuk University)
Lee, Choong-Soo (College of Pharmacy, Woosuk University)
Jang, Yu-Jung (Department of Food and Nutrition, Yonsei University)
Park, Jeong-Woo (Department of Food and Nutrition, Yonsei University)
Yoon, Sun (Department of Food and Nutrition, Yonsei University)
Publication Information
Korean Journal of Food Science and Technology / v.39, no.6, 2007 , pp. 694-700 More about this Journal
Abstract
Acanthopanax senticosus is a common Asian herb also known as "Siberian Ginseng". It is often used as a traditional herbal medicine for reducing damage in the liver, kidney, bone and muscle. In the present study we investigated the ferric reducing/antioxidant power and total phenolic contents of the ethanol-/water-extracts obtained from the stems and leaves of Acanthopanax senticosus. Osteoblast cellular proliferation was evaluated using the MTT and alkaline phosphatase activity assays in the human osteoblast-like MG-63 cell line. Acanthopanax senticosus extracts exerted remarkable ferric reducing/antioxidant power and contained high amount of phenolics. Among the extracts the stem-/ethanol-extract showed the highest antioxidant activity and total phenol content. Interestingly a highly positive correlation was found between antioxidant activity and total phenol content (p < 0.01). Proliferation of MG-63 osteoblast cells was highest in the stem-/ethanol-extract and alkaline phosphatase activity significantly increased in the water-extract of the stems (p < 0.05). These findings suggest that Acanthopanax senticosus extracts have antioxidant activity for preventing oxidative stress-related diseases and may have beneficial effects on bone health through the proliferation of osteoblast cells.
Keywords
Acanthopanax senticosus; antioxidative activity; total phenol content; human osteoblast-like MG-63 cell line; alkaline phosphatase activity;
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Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By SCOPUS : 4
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