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Antimicrobial Effect of Achyranthes japonica Nakai Extracts against Clostridium difficile  

Jung, Sun-Mi (Department of Biological Engineering, Inha University)
Choi, Soo-Im (Department of Biological Engineering, Inha University)
Park, Sang-Min (Department of Biological Engineering, Inha University)
Heo, Tae-Ryeon (Department of Biological Engineering, Inha University)
Publication Information
Korean Journal of Food Science and Technology / v.39, no.5, 2007 , pp. 564-568 More about this Journal
Abstract
In this study, the ethanolic extracts of 40 species of traditional herbal medicines were examined for their antimicrobial activities against Clostridium difficile. Among the 43 screened traditional herbal medicines, Achyranthes Japonica Nakai (AJN), Siegesbeckia glabrescens Makino, and Phelloedendron amurense Ruprecht showed antimicrobial activities greater than 90% at a concentration of 500 ppm. According to the minimum inhibitory concentration (MIC) test the ethyl acetate soluble fraction of the AJN ethanolic extracts (AJNEA) showed the highest growth inhibitory activity against C. difficile, with a MIC of $625{\mu}g/mL$. In addition, the effect of AJNEA on the growth of lactic acid bacteria was investigated. AJNEA did not inhibit the growth of the tested Bifidobacterium spp. or Lactobacillus spp., with the exception of B. longum, Streptococcus thermophilus, and L. helveticus. These results indicate that AJNEA can be utilized as a potential antimicrobial agent against C. difficile related disease.
Keywords
Achyranthes japonica Nakai; antimicrobial effect; lactic acid bacteria; Clostridium difficile; minimum inhibitory concentration;
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Times Cited By KSCI : 4  (Citation Analysis)
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