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Inhibitory Effects of Fungal Metabolites Isolated from Foodstuffs on the Growth of Human Cancer Cell Lines  

Im, Hyo-Gwon (Department of Food Science and Technology, Keimyung University)
Yu, Mi-Hee (Department of Food Science and Technology, Keimyung University)
Chung, Duck-Wha (Division of Applied Life Science, Gyeongsang National University)
Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
Publication Information
Korean Journal of Food Science and Technology / v.38, no.2, 2006 , pp. 262-267 More about this Journal
Abstract
Inhibitory effects of fungal metabolites isolated from foodstuffs on growth of human cancer cell lines were evaluated. Isolated strains were divided into four classes based on color (aerial, reverse), shape, and growth speed. Fungal metabolites extracted with ethyl acetate were investigated for their growth inhibition on six kinds of human cancer cells by MTT assay. Ethyl acetate extract showed high growth inhibition against all cancer cells tested, with D4 exhibiting the strongest growth inhibition effects against Kato III, AGS, Hepa1c1c7, and MDA-MB-231 cancer cells. These results suggest ethyl acetate extract from fungal metabolites as effective natural cancer therapeutic material.
Keywords
fungi; fungal metabolites; cytotoxicity; anticancer;
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