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Hepatoprotective Effect of Cheonnyuncho (Opuntia humifusa) Extract in Rats Treated Carbon Tetrachloride  

Park, Min-Kyung (Department of Human Nutrition and Food Science Chungwoon University)
Lee, Young-Jae (Department of Veterinary Medicine, Cheju National University)
Kang, Eun-Sil (Department of Human Nutrition and Food Science Chungwoon University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.5, 2005 , pp. 822-826 More about this Journal
Abstract
Effect of Cheonnyuncho extract on the liver injury of rats treated carbon tetrachloride $(CCl_4)$ was studied. Cheonnyuncho extract was administerd at dose of 0.5 and 1 g/kg/day, p.o. for 2 weeks. $CCl_4$ was treated at dose of $0.5\;mL/kg$, i.p. 3 hours later from the last pretreatment of Cheonnyuncho extract. Administration of Cheonnyuncho extract at a dose of 1 g/kg decreased serum AST, ALT and ALP activities by 36, 41, and 22% respectively compared to $CCl_4$ treatment group. Increased lipid peroxidation and decreased SOD and GST activities were also recovered by pretreatment of Chonnyuncho extract in liver of rats. These results suggest that Cheonnyuncho extract has hepatoprotective effect against liver injury.
Keywords
Cheonnyuncho; liver; $CCl_4$; AST; ALT; antioxidant enzymes;
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Times Cited By KSCI : 2  (Citation Analysis)
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