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Cholesterol-Lowering Effect of Pine Nut in Plasma of Rats  

Park, Young-Seo (Division of Biotechnology, Kyungwon University)
Chung, Myong-Soo (Department of Packaging, Yonsei University, Institute of Functional Biomaterials and Biotechnology, Yonsei University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.5, 2005 , pp. 702-708 More about this Journal
Abstract
Cholesterol-lowering effect of pine nut on mice was investigated by examining changes in body weight, feed intake, and triglyceride, total cholesterol, high density liporotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) contents in mice plasma. Changes in body weight and feed intake between pre-designed experimental animal groups fed various contents of cholesterol and pine nut and control group fed basal diet were not significantly different. Food efficiency ratio of experimental groups fed higher than 10% pine nut was significantly higher than that of control group. Apparent differences in atherogenic index representing cholesterol-lowering effect in plasma were not found among all groups fed 0-20% pine nut. Inhibition activities of water and hexane extracts of pine nut on HMG-CoA reductase and cholesterol esterase were examined in vitro. Hexane extract showed 66% inhibition effect on HMG-CoA reductase, whereas none was observed with water extract.
Keywords
pine nut; cholesterol; atherogenic index; HMG-CoA reductase; cholesterol esterase;
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