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Effects of Mulberry Leaves Powder on Lipid Metabolism in High Cholesterol-Fed Rats  

Kim, Ae-Jung (Department of Food & Nutrition of Hyejeon College)
Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyunghee University)
Choi, Mi-Kyeong (Department of Human Nutrition & Food Science of Chungwoon University)
Kim, Myung-Hwan (Department of Food Engineering of Dankook University)
Han, Myung-Ryun (Department of Food Engineering of Dankook University)
Chung, Kun-Sub (Department of Biological Resources & Technology, Yonsei University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.4, 2005 , pp. 636-641 More about this Journal
Abstract
Mulberry leaves, high in dietary fiber and some nutritional materials, are thought to have hypocholesterolemic effect. Therefore, effect of mulberry leaf powder on serum lipid profiles were studied using rats with diet-induced hypercholesterolemia. Male Sprague-Dawley rats were fed AIN-93 diet (control group), and diets containing high-cholesterol and 0% mulberry leaves powder, high-cholesterol and 5% mulberry leaves powder, and high-cholesterol and 10% mulberry leaves powder for 4 weeks. Hypercholesterolemia was induced by adding 1% cholesterol and 0.5% cholic acid to all diets except in control group. Although no differences were observed in food intake and initial body weight among groups, mulberry leaf treatment resulted in significant decreases in food efficiency ratio and body weight gain. Mulberry leaf treatment decreased serum lipid profiles, atherogenic index, cardiac risk factor, low density lipoprotein cholesterol ratio, serum aspartate transaminase, and liver lipid levels. High density lipoprotein cholesterol, total cholesterol, serum HDL-cholesterol, and fecal lipid levels increased, suggesting mulberry leaves could improve hyperlipidemia and liver action, thereby proventing cardiovascular disease.
Keywords
mulberry leaves powder; lipid profiles; cardiovascular disease index;
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