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Hypolipidemic Effects of Glycoprotein Isolated from Ficus Carica Linnoeus in Mice  

Lim, Kye-Taek (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University)
Lee, Sei-Jung (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University)
Ko, Jeong-Hyeon (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University)
Oh, Phil-Sun (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.4, 2005 , pp. 624-630 More about this Journal
Abstract
Glycoprotein (60 kDa) isolated from Ficus Carica Linnoeus (FCL glycoprotein) was examined by evaluating its hypolipidemic effects on plasma cholesterol levels and hepatic detoxicant enzyme activities in ICR mice. FCL glycoprotein $(100{\mu}g/mL)$ had strong scavenging activities (38%) against lipid peroxyl radicals. When mice were treated with Triton WR-1339 (400 mg/kg), levels of total cholesterol (TC) and low-density lipoprotein (LDL)-cholesterol in plasma significantly increased by 53.9 and 47.5 mg/dL, respectively, compared to the control, whereas, when pretreated with FCL glycoprotein $(100{\mu}g/mL)$, decreased remarkably by 55.4, and 47,0 mg/dL, compared to Triton WR-1339 treatment alone. Interestingly, high-density lipoprotein (HDL)-cholesterol level did not change. Body and liver weights did not change significantly after Triton WR-1339 treatment in presence of FCL glycoprotein. FCL glycoprotein $(100{\mu}g/mL)$ stimulated activities of antioxidative detoxicant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), whereas GPx activity significantly increased compared to the control. These results suggest FCL glycoprotein has abilities to scavenge lipid peroxyl radicals, lower plasma lipid levels, and stimulate detoxicant enzyme activity in mouse liver.
Keywords
Ficus Carica Linnoeus (FCL); glycoprotein; plasma cholesterol; detoxicant enzymes;
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